761433-08-3Relevant academic research and scientific papers
Synthesis of the fully functionalized nine-membered diyne core of the C-1027 chromophore
Inoue, Masayuki,Kikuchi, Tsukasa,Hirama, Masahiro
, p. 6439 - 6442 (2004)
We report the synthesis of the fully functionalized seco-acid of the C-1027 chromophore. The key reaction is a LiN(TMS)2/CeCl 3-promoted acetylide-aldehyde condensation to construct the highly strained nine-membered diyne. Appropriate functionalization of the substrates significantly affects the yield of the cyclization. The present findings will be the basis of further studies toward the total synthesis of the C-1027 chromophore.
