761435-31-8

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-N-isopropylbenzenesulfonamide is used as an antibacterial agent for the treatment of urinary tract infections and other bacterial infections. It is administered orally and is well-absorbed in the body, reaching peak plasma concentrations within 1-2 hours after ingestion. Its effectiveness in inhibiting bacterial growth makes it a valuable component in the management of bacterial infections.
Used in Medicinal Formulations:
2-amino-N-isopropylbenzenesulfonamide is used as an active pharmaceutical ingredient in various formulations, such as tablets and capsules, to provide targeted treatment for bacterial infections. Its formulation into different dosage forms allows for convenient administration and compliance by patients.

InChI:InChI=1/C9H14N2O2S/c1-7(2)11-14(12,13)9-6-4-3-5-8(9)10/h3-7,11H,10H2,1-2H3

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 23530-42-9 N-isopropyl-2-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

Nickel-catalyzed regio- and enantioselective annulation reactions of 1,2,3,4-benzothiatriazine-1,1(2H)-dioxides with allenes

(Figure Presented) Extrusion of N2:1,2,3,4-Benzothiatriazine1,1 (2H)-dioxides reacted with alienes in the presence of a nickel (0)/(R)-quinap complex to produce a variety of substituted 3,4-dihydro-1,2-benzothiazine1,1 (2H)-dioxides in a regio- and enantioselective fashion. An intermediate nickelacycle was generated through denitrogenative activation of the triazo moiety which allowed the intermolecular incorporation of an aliene group. quinap = 1-(2diphenylphosphino-1-naphthyl)isoquinoline.

INHIBITORS OF FOCAL ADHESION KINASE

The invention provides inhibitors of focal adhesion kinase, an enzyme involved in the attachment of the cytoskeleton of a cell to an extracellular matrix, which has been implicated in processes such as cell migration, cell proliferation, and cell survival. The inhibitors are derivatives of a 5-substituted 2,4-diaminopyridine wherein the substituents are as defined herein. The invention also provides a method of using the inhibitors in treatment of cancer, and methods of preparation of the inhibitors by use of coupling reactions.