761442-95-9

Upstream product

• 75-66-1 2-methylpropan-2-thiol 
• 761442-94-8 2-bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 
• 761442-93-7 2-bromo-N-[2-(5-chloro-2-methoxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 

Downstream Products

• 851286-19-6 4-(5-chloro-2-hydroxy-phenyl)-3-(4-methoxy-2-oxo-butylsulfanyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 765955-21-3 4-(5-Chloro-2-hydroxy-phenyl)-3-[4-(4-methyl-piperazin-1-yl)-2-oxo-butylsulfanyl]-6-trifluoromethyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

4-Aryl-3-(mercapto)quinolin-2-ones: Novel maxi-K channel opening relaxants of corporal smooth muscle

A novel series of 4-aryl-3-(mercapto)quinolin-2-one derivatives was prepared and evaluated as openers of the cloned maxi-K channel hSlo expressed in Xenopus laevis oocytes by utilizing electrophysiological methods. The effect of these maxi-K openers on co

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

A series Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinine core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavemo