761447-77-2Relevant academic research and scientific papers
Biphenol-based phosphoramidite ligands for the enantioselective copper-catalyzed conjugate addition of diethylzinc
Alexakis, Alexandre,Polet, Damien,Rosset, Stephane,March, Sebastien
, p. 5660 - 5667 (2007/10/03)
Phosphoramidite ligands, based on ortho-substituted biphenols and a chiral amine, induce high enantioselectivities (ee's up to 99%) in the copper-catalyzed conjugate addition of dialkylzinc reagents to a variety of Michael acceptors. Particularly, the best reported ee's were obtained for acyclic nitroolefins.
