761457-20-9Relevant academic research and scientific papers
Pd-Cu bimetallic catalyzed domino cyclization of α-allenols followed by a coupling reaction: New sequence leading to functionalized spirolactams
Alcaide, Benito,Almendros, Pedro,Rodriguez-Acebes, Raquel
, p. 5708 - 5712 (2005)
A novel regioselective metal-catalyzed spirocyclization of α-allenolscross coupling (Heck, Sonogashira, and Suzuki) reaction sequence, leading to potentially bioactive spirocyclic lactam derivatives has been developed. Precursors for the tandem spirocycli
Direct allenol-based stereocontrolled access to substituted (E)-1,3-enynes
Alcaide, Benito,Almendros, Pedro,Martínez Del Campo, Teresa
, p. 7603 - 7609 (2012/10/29)
A stereoselective synthesis of 1-substituted (E)-2-aryl-but-1-en-3-ynes, including tetrasubstituted alkenes, has been developed from aryl-substituted α-allenols by treatment with the AcCl-NaOH (aqueous) system. This transformation might be explained throu
Divergent reactivity of 2-azetidinone-tethered allenols with electrophilic reagents: Controlled ring expansion versus spirocyclization
Alcaide, Benito,Almendros, Pedro,Luna, Amparo,Torres, M. Rosario
supporting information; experimental part, p. 621 - 626 (2010/07/06)
A dual reactivity of 2-azetidinone-tethered allenols may occur by judicious choice of the electrophilic reagents, namely halogenating versus selenating reagents. Using common substrates, structurally different compounds, namely tetramic acids (from N-bromosuccinimide) or spirocyclic seleno-ss-lactams (from N-phenylselenophthalimide), can be readily synthesized by these divergent protocols.
Diversity-oriented preparation of enantiopure spirocyclic 2-azetidinones from α-oxo-β-lactams through barbier-type reactions followed by metal-catalyzed cyclizations
Alcaide, Benito,Almendros, Pedro,Del Campo, Teresa Martinez,Rodriguez-Acebes, Raquel
, p. 749 - 758 (2008/02/10)
Novel, simple, and convenient strategies to diversely functionalized spirocyclic β-lactams have been developed by using different metal-mediated carbonyl addition/cyclization reaction sequences. Spirocyclization precursors, 2-azetidinone-tethered homoally
Metal-assisted synthesis of enantiopure spirocyclic β-lactams from azetidine-2,3-diones
Alcaide, Benito,Almendros, Pedro,Martínez-Del Campo, Teresa,Rodríguez-Acebes, Raquel
, p. 6429 - 6431 (2007/10/03)
A novel approach to enantiopure spirocyclic β-lactams has been developed by using different intramolecular metal-catalyzed cyclization reactions in monocyclic unsaturated alcohols. A novel approach to enantiopure spirocyclic β-lactams has been developed b
