761460-03-1

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-4-Boc-3-morpholineacetic acid is used as a key intermediate in the synthesis of pharmaceuticals for its ability to facilitate the creation of complex molecular structures. The Boc protecting group enhances its stability and reactivity during the synthesis process, making it a preferred choice for developing new drugs.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-4-Boc-3-morpholineacetic acid is used as a versatile building block for the construction of various organic compounds. Its specific reactivity and the presence of the Boc group allow for the efficient synthesis of a wide range of molecules, contributing to the advancement of organic chemistry research.
Used in Peptide Synthesis:
(R)-4-Boc-3-morpholineacetic acid is employed as a crucial component in peptide synthesis, where the Boc protecting group plays a significant role in protecting the amino acid during the synthesis process. This ensures the successful formation of peptide bonds and the production of desired peptide sequences.
Used in Drug Discovery Research:
As a valuable tool in drug discovery research, (R)-4-Boc-3-morpholineacetic acid aids in the exploration of new drug candidates and the optimization of existing ones. Its unique properties and reactivity contribute to the development of innovative therapeutic agents with improved efficacy and selectivity.

InChI:InChI=1/C11H19NO5/c1-11(2,3)17-10(15)12-4-5-16-7-8(12)6-9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1

Upstream product

• 761460-02-0 tert-Butyl 3-(2-ethoxy-2-oxoethyl)morpholine-4-carboxylate 
• 81684-84-6 ethyl 2-(morpholin-3-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 86236-84-2 2-(morpholin-3-yl)acetic acid 
• 813433-72-6 (4-formyl-morpholin-3-yl)-acetic acid 

Downstream Products

• 1398397-37-9 methyl 3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)-5-(trifluoromethyl)benzoate 
• 1398397-43-7 methyl 3-(3-(2-(((R)-1-(naphthalen-1-yl)ethyl)amino)ethyl)morpholino)-5-(trifluoromethyl)benzoate 

Relevant academic research and scientific papers

SUBSTITUTED MORPHOLINES AS MODULATORS FOR THE CALCIUM SENSING RECEPTOR

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (CaSR) receptors of Formula (I).

SUBSTITUTED MORPHOLINES AS MODULATORS FOR THE CALCIUM SENSING RECEPTOR

Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (Ca SR) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of calcium sensing (Ca SR) receptors of Formula (I).

Process for producing enantiopure beta-amino acid derivatives, and enantiopure beta-amino acid derivatives

Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2—CH2—COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or an organic residue, and Z represents H or an amino function-protecting group, comprising a step in which a mixture of enantiomers of a compound corresponding to general formula (II) R1-NZ-CHR2—CH2—COOR4 (II) in which R1, R2 and Z are as defined for formula (I), and R4 is an organic residue, is subjected to hydrolysis in the presence of a lipase.

An efficient synthesis of chiral cyclic β-amino acids via asymmetric hydrogenation

Cyclic β-amino acids, homoproline, homopipecolic acid and 3-carboxy-methylmorpholine were obtained in high enantiomeric excesses by transition metal-catalyzed asymmetric hydrogenation of cyclic β-acylamino-alkenoates. These compounds were synthesized by a

Enzymatic resolution of cyclic N-Boc protected β-aminoacids

Methyl and ethyl esters of N-Boc homoproline, homopipecolic acid and 3-carboxymethyl-morpholine were kinetically resolved by hydrolysis catalysed by Burkholderia cepacia lipase to give the corresponding acids and residual esters in enantiomeric excesses better than 99% (E > 100).