76162-71-5Relevant academic research and scientific papers
Cyclodimerization of Vinylpyridines
Terent'ev, P. B.,Kartsev, V. G.,Gorelov, A. V.,Gloriozov, I. P.,Gulevich, Yu. A.,Kost, A. N.
, p. 945 - 950 (1980)
When isomeric 2- and 4-vinylpyridines, as well as 2-methyl-5-vinylpyridine, are heated in polyphosphoric or acetic acid, they undergo dimerization, which proceeds via a 1,4-cycloaddition scheme to give pyridyl-substoituted 5,6,7,8-tetrahydroquinolines or isoquinolines.Quantum-chemical calculations with the use of the concepts of molecular orbital perturbation theory make it possible to predict the regiospecificity of the reaction.The regiospecific cross cycloaddition of 4-vinylpyridine to 2-methyl-5-vinylpyridine was proposed theoretically and proven experimentally.
