76166-59-1

Usage

Uses

Used in Pharmaceutical Industry:
Derrone is used as a potential anticancer agent for its ability to inhibit the growth of various cancer cells, including breast and prostate cancer cells. Its mechanism of action involves inducing cell cycle arrest and apoptosis, as well as inhibiting the expression of proteins involved in cancer progression.
Used in Cancer Therapy Research:
Derrone is used as a subject of research to further understand its mechanisms of action and potential therapeutic applications in cancer treatment. Its anti-inflammatory properties, which contribute to its potential as a cancer therapy, are of particular interest, as inflammation is known to play a role in the development and progression of cancer.
Further research is needed to fully explore the potential of Derrone in cancer treatment and to develop effective drug delivery systems that can enhance its bioavailability and therapeutic outcomes.

Upstream product

• 109517-68-2 5-hydroxy-3(4'-hydroxy)phenyl-8,8-dimethyl-9,10-dihydro-4H,8H-benzo<1,2b:5,6b'>dipyran-4-one 
• 141737-97-5 3-(4-Benzyloxy-phenyl)-5-hydroxy-8,8-dimethyl-8H-pyrano[2,3-f]chromen-4-one 
• 104691-86-3 lupiwighteone 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 95165-66-5 3-Iod-2-hydroxy-4,6-dibenzyloxy-acetophenon 
• 104691-92-1 lupiwighteone hydrate 
• 160154-81-4 4',6'-bis(benzyloxy)-3'-iodo-2'-(methoxymethoxy)acetophenone 
• 210166-25-9 (E)-3-(4-Benzyloxy-phenyl)-1-(4,6-bis-benzyloxy-2-hydroxy-3-iodo-phenyl)-propenone 
• 210166-28-2 5,7-Bis-benzyloxy-3-(4-benzyloxy-phenyl)-8-iodo-chromen-4-one 
• 210166-33-9 4',7-bis(benzoyloxy)-5-acetoxy-8-(3-methyl-2-butenyl)isoflavone 
• 210166-26-0 Acetic acid 3,5-bis-benzyloxy-2-[(E)-3-(4-benzyloxy-phenyl)-acryloyl]-6-iodo-phenyl ester 
• 210166-29-3 5,7-Bis-benzyloxy-3-(4-benzyloxy-phenyl)-8-(3-hydroxy-3-methyl-but-1-ynyl)-chromen-4-one 
• 210166-30-6 4',5,7-tris(benzoyloxy)-8-(3-hydroxy-3-methylbutyl)isoflavone 
• 210166-27-1 Acetic acid 3,5-bis-benzyloxy-2-[2-(4-benzyloxy-phenyl)-3,3-dimethoxy-propionyl]-6-iodo-phenyl ester 

Downstream Products

• 34086-52-7 5-hydroxy-3(4'-methoxy)phenyl-8,8-dimethyl-4H,8H-benzo<1,2b:5,6b'>dipyran-4-one 

Relevant academic research and scientific papers

Regioselective Synthesis of Prenylisoflavones. Syntheses of Lupiwighteone, Lupiwighteone Hydrate and Related Compounds

The palladium-catalyzed coupling reaction of 4',5.7-tris(benzyloxy)-8-iodoisoflavone 11, synthesized from the 3'-iodochalcone 8, with 2-methyl-3-butyn-2-ol gave the corresponding 8-(3-hydroxy-3-methylbutynyl)isoflavone 12.Catalytic hydrogenation of 12 gav

SYNTHESIS OF 4',5- AND 3',4',5-OXYGENATED PYRANOISOFLAVONES: ALPINUM ISOFLAVONE AND RELATED COMPOUNDS, AND REVISED STRUCTURE OF DERRONE

Alpinumisoflavone (4',5-dihydroxy-2",2"-dimethylpyranoisoflavone) (1a) was synthesized by regioselective reduction of 7-(4-hydroxyphenyl)-2,3-dihydro-5-methoxy-2,2-dimethyl-4H,6H-benzodipyran-4,6-dione (15a) with NaBH4 and dehydrati

SYNTHESIS OF ALPINUM ISOFLAVONE, DERRONE AND RELATED PYRANOISOFLAVONES

Reaction of phenacylchroman 1 with ethoxyalyl chloride in pyridine followed by hydrolysis of the resulting esters 2 and 3 and decarboxylation of the acids 4 and 5, gave dihydro-4'-O-methyl alpinum isoflavone 6 and 4'-O-methylderrone 7 respectively.Similarly 8 gave 11 which was selectively demethylated to 7.DDQ, dehydrogenation of 6, 7 and 11 gave 14, 15 and 17.Demethylation of 6 and 7 followed by dehydrogenation gave alpinum isoflavone 18 and derrone 19.