76182-42-8Relevant academic research and scientific papers
Photocyclization of enamines to access Spiroindolines and Spirooxindoles in continuous flow
Moustakim, Moses,Ledford, Brian,Garwin, Jacob A.,Boyd, Michael J.
, (2020)
We report an expedited flow chemistry approach to the catalyst/photosensitizer-free UV photocyclizations of aryl-enamines to afford spiroindolines. The photocyclizations occur under mild conditions and are tolerant to a variety of substituted aryl-enamine
Spiroaziridination of cycloalkylidene esters under high pressure
Rulev, Alexandre,Maddaluno, Jacques
, p. 2569 - 2576 (2007/10/03)
The reaction between primary amines and 2-bromo-2-(cycloalkylidene)acetates in alcohol under high pressure provides the expected spiroaziridines in good yields and diastereomeric excesses. With bulky or aromatic amines, this reaction competes with the migration of the double bond, which, migrating from an exo to an endocyclic position, provides an intermediate allylic α-bromo ester, immediately converted into an α-amino ester. It was also possible to develop a tandem version, applying the same high pressure conditions to a 1,4-bis-cyclohexylidene acetate. The corresponding bisspiroaziridine was obtained in good yield and moderate de. However, this reaction did not succeed with 2-chloro-2-(cyclopropylidene)acetate, which produced only glutaric acid derivatives in low yields.
HETEROATOM DIRECTED PHOTOARYLATION. SYNTHESIS OF FUNCTIONALIZED INDOLINES
Schultz, Authur G.,Sha, Chin-Kang
, p. 1757 - 1761 (2007/10/02)
The photochemical syntheses of indolines 25-28 are described.
