76188-95-9 Usage
Description
(R)-5-CHLORO-2-PENTANOL, with the molecular formula C5H11ClO, is an organic compound characterized by the presence of a chlorine atom and a hydroxyl group. This clear, colorless liquid is slightly soluble in water and is miscible with most organic solvents. It serves as a versatile intermediate in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
(R)-5-CHLORO-2-PENTANOL is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new medications.
Used in Agrochemical Industry:
(R)-5-CHLORO-2-PENTANOL is used as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect and enhance crop yields.
Used in Fragrance Industry:
(R)-5-CHLORO-2-PENTANOL is used as an intermediate in the synthesis of fragrances, contributing to the development of new scents for various applications.
Used as a Chiral Building Block:
(R)-5-CHLORO-2-PENTANOL is used as a chiral building block in the synthesis of chiral pharmaceuticals and other fine chemicals, highlighting its importance in the production of enantiomerically pure compounds.
It is crucial to handle (R)-5-CHLORO-2-PENTANOL with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin.
Check Digit Verification of cas no
The CAS Registry Mumber 76188-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,1,8 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 76188-95:
(7*7)+(6*6)+(5*1)+(4*8)+(3*8)+(2*9)+(1*5)=169
169 % 10 = 9
So 76188-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H11ClO/c1-5(7)3-2-4-6/h5,7H,2-4H2,1H3/t5-/m0/s1
76188-95-9Relevant articles and documents
Practical application of recombinant whole-cell biocatalysts for the manufacturing of pharmaceutical intermediates such as chiral alcohols
Matsuyama, Akinobu,Yamamoto, Hiroaki,Kobayashi, Yoshinori
, p. 558 - 561 (2013/09/06)
We have developed efficient biocatalytic processes for the preparation of chiral alcohols, such as (R)-1,3-butanediol, ethyl (S)-4-chloro-3-hyroxybutanoate, ethyl (R)-4-chloro-3-hyroxybutanoate, (S)-5-chloro-2-pentanol, (R)-5-chloro-2-pentanol, and (S)-cyclopropylethanol by stereospecific enzymatic oxidoreduction on a practical level. These chiral alcohols are very important synthons for the synthesis of various pharmaceutical intermediates that lead to antibiotics and inhibitors of HMG-CoA reductase. Here, we present practical applications on biocatalysis using novel recombinant whole-cell biocatalysts that catalyzed enantioselective oxidation and asymmetric reduction with a coenzyme regeneration system.
Lactobacillus kefir Alcohol Dehydrogenase: A Useful Catalyst for Synthesis
Bradshaw, Curt W.,Hummel, Werner,Wong, Chi-Huey
, p. 1532 - 1536 (2007/10/02)
The alcohol dehydrogenase from Lactobacillus kefir simultaneously catalyzes carbonyl reductions and NADPH regeneration in the presence of 2-propanol.Representative synthesis of a number of chiral alcohols was accomplished in good yield and high enantiomeric excess (94-99percent).This NADPH-requiring enzyme transfers the pro-R hydride from the cofactor to the si face of carbonyls to give (R) alcohols.The enzyme exhibits a very broad substrate specificity and high enantioselectivity for the synthesis of chiral aromatic, cyclic, polycyclic, and aliphatic alcohols.
