76191-51-0Relevant articles and documents
Regioselective lactonization of naphthoquinones: Synthesis and antitumoral activity of the WS-5995 antibiotics
Qabaja, Ghassan,M. Perchellet, Elisabeth,Perchellet, Jean-Pierre,Jones, Graham B.
, p. 3007 - 3010 (2007/10/03)
An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS- 5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis. (C) 2000 Elsevier Science Ltd.
THE TOTAL SYNTHESIS OF THE ANTI-COCCIDIAL AGENTS WS-5995
McKenzie, Thomas C.,Choi, Woo-Baeg
, p. 1523 - 1532 (2007/10/02)
A total synthesis of the three anti-coccidial agents WS-5995 A, B, and C by a Diels-Alder route is described.An intramolecular lactonization involving the displacement of a chlorine atom on a napthoquinone was the key step in the synthesis of A.
1,4-Naphtoquinone derivatives and their use in treating coccidiosis
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, (2008/06/13)
1,4-naphthoquinone derivatives represented by the following general formula: STR1 (wherein R1 represents a hydrogen atom, a hydroxy group, a lower alkoxy group or an arylthio group, R2 represents a carboxy group, an esterified carbox