76195-82-9

Basic information

• Product Name: 2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE
• Synonyms: BIO-FARMA BF000367;1-MESITYLHYDRAZINE HYDROCHLORIDE;2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE;Mesitylhydrazine hydrochloride;2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHL&;MesitylhydrazineHCl;2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE (MESITYLHYDRAZINE HYDROCHLORIDE);Mesitylhydrazine hydrochloride, 2-Hydrazinomesitylene hydrochloride
• CAS NO: 76195-82-9
• Molecular Formula: C₉H₁₄N₂*ClH
• Molecular Weight: 186.68
• EINECS: -0
• Product Categories: Hydrazines;Nitrogen Compounds;Organic Building Blocks
• Mol File: 76195-82-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 300 °C
• Boiling Point: 226.9 °C at 760 mmHg
• Flash Point: 103.6 °C
• Appearance: /
• Vapor Pressure: 0.0797mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility: Soluble in water.
• BRN: 3700289
• CAS DataBase Reference: 2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE(76195-82-9)
• EPA Substance Registry System: 2,4,6-TRIMETHYLPHENYLHYDRAZINE HYDROCHLORIDE(76195-82-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 76195-82-9(Hazardous Substances Data)

Usage

Uses

2,4,6-Trimethylphenylhydrazine hydrochloride is used as pharmaceutical intermediates.

InChI:InChI=1/C9H14N2.ClH/c1-6-4-7(2)9(11-10)8(3)5-6;/h4-5,11H,10H2,1-3H3;1H

Upstream product

• 88-05-1 2,4,6-trimethylaniline 

Downstream Products

• 955378-07-1 (Z)-1-mesityl-2-((4aS,9aR)-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-ylidene)hydrazine hydrochloride 
• 955103-17-0 2-mesityl-1-(pyrrolidin-2-ylidene)hydrazinium chloride 
• 1345817-96-0 (Z)-2-mesityl-1-((4aR,9aS)-4,4a,9,9a-tetrahydroindeno[2,1b][1,4]oxazin-3(2H)-ylidene)hydrazine hydrochloride 
• 1449522-19-3 (S)-5-sec-butyl-2-mesityl-6,8-dihydro-5H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2-ium chloride 
• 384-98-5 2,4,6-trimethylbenzene-1-sulfonyl fluoride 
• 88-05-1 2,4,6-trimethylaniline 

Relevant articles and documents

1,4-Bis-Dipp/Mes-1,2,4-Triazolylidenes: Carbene Catalysts That Efficiently Overcome Steric Hindrance in the Redox Esterification of α- And β-Substituted α,β-Enals

As reported by Scheidt and Bode in 2005, sterically nonencumbered α,β-enals are readily converted to saturated esters in the presence of alcohols and N-heterocyclic carbene catalysts, e.g., benzimidazolylidenes or triazolylidenes. However, substituents at the α- or β-position of the α,β-enal substrate are typically not tolerated, thus severely limiting the substrate spectrum. On the basis of our earlier mechanistic studies, a set of N-Mes- or N-Dipp-substituted 1,2,4-triazolium salts were synthesized and evaluated as (pre)catalysts in the redox esterification of various α- or β-substituted enals. In particular the 1,4-bis-Mes/Dipp-1,2,4-triazolylidenes overcome the above limitations and efficiently catalyze the redox esterification of a whole series of α/β-substituted enals hitherto not amenable to NHC-catalyzed transformations. The synthetic value of 1,4-bis-Mes/Dipp-1,2,4-triazolylidenes is further demonstrated by the one-step bicyclization of 10-oxocitral to (racemic) nepetalactone in diastereomerically pure form.

α-Aroyloxyaldehydes: Scope and limitations as alternatives to α-haloaldehydes for NHC-catalysed redox transformations

α-Aroyloxyaldehydes are readily prepared bench stable synthetic intermediates. Their ability to act as α-haloaldehyde surrogates for NHC-promoted redox esterifications and in [4+2] cycloadditions is described.

ENANTIOSELECTVE REACTIONS CATALYZED BY CHIRAL TRIAZOLIUM SALTS

This invention provides a convenient method for converting imines and other electrophiles into heterocyclic ring systems. The process does not require the use of metallic reagents, and is catalyzed by an organic heterocyclic carbene catalyst. Accordingly,