76196-68-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromomethyl-pyrimidine-2-carboxylic acid methyl ester is used as a synthetic intermediate for the development of pharmaceutical compounds with specific therapeutic applications. Its unique molecular structure allows for the creation of novel drugs with potential benefits in treating various medical conditions.
Used in the Preparation of Antifibrinolytics:
In the pharmaceutical industry, 5-Bromomethyl-pyrimidine-2-carboxylic acid methyl ester is used as a key component in the synthesis of aza analogs of 4-aminomethylbenzoic acid. These aza analogs possess antifibrinolytic properties, which can be beneficial in the treatment of conditions related to excessive bleeding or clotting disorders. 5-Bromomethyl-pyrimidine-2-carboxylic acid methyl ester's reactivity and structural features make it an essential building block in the development of these potential therapeutic agents.

Upstream product

• 76196-80-0 Methyl 5-methylpyrimidine-2-carboxylate 
• 22536-61-4 2-chloro-5-methylpyrimidine 

Downstream Products

• 76196-72-0 5-Aminomethylpyrimidine-2-carboxylic acid 

Relevant academic research and scientific papers

SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1

Provided are compounds of Formula (I): (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.

1,3,4-OXADIAZOLE SULFONAMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds represented by the formula I having histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. (I) The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases.

LSD1 INHIBITORS AND USES THEREOF

Provided are novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSDl. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSDl.

Medicinal Chemical Studies on Antiplasmin Drugs. VI. Aza Analogs of 4-Aminomethylbenzoic Acid

Four aza analogs of 4-aminomethylbenzoic acid (1) were prepared as part of a search for new antiplasmin drugs. 5-Aminomethylpyridine-2-carboxylic acid (5) was prepared by the hydrogenation of methyl 5-cyanopyridine-2-carboxylate (4), followed by alkaline hydrolysis.Similarly, 6-aminomethylpyridine-3-carboxylic acid (7) was prepared from ethyl 6-cyanopyridine-3-carboxylate (6). 5-Aminomethylpyrimidine-2-carboxylic acid (12) was obtained from methyl 5-methylpyrimidine-2-carboxylate (8) via the phthalimido derivative (10). 2-Aminomethylpyrimidine-5-carboxylic acid (25) was obtained by the reaction of benzyloxycarbonylaminoacetamidine (22) with ethoxycarbonylmalonaldehyde (18) in acetic acid, followed by deblocking of the protected groups.Treatment of benzoylaminoacetamidine (14) with acetylacetone (15) in acetic acid provided 2-benzoylaminomethyl-4,6-dimethylpyrimidine (16), whereas in the presence of K2CO3, 2-amino-3-benzoylamino-4,6-dimethylpyridine (17) was obtained together with a trace of 16.No compound showed more potent antiplasmin activity than tranexamic acid (2), but 5 was more active than 1.Keywords - antiplasmin drug; 4-aminomethylbenzoic acid; tranexamic acid; bioisostere; aminomethylpyridinecarboxylic acid; aminomethylpyrimidinecarboxylic acid; pyridine ring closure; pyrimidine ring closure; benzoylaminoacetamidine; benzyloxycarbonylaminoacetamidine