7621-94-5Relevant academic research and scientific papers
3, 5-disubstituted hydantoin compound as well as preparation method and application thereof
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Paragraph 0042; 0041; 0051; 0052; 0057; 0058, (2018/10/19)
The invention provides a 3, 5-disubstituted hydantoin compound as well as a preparation method and an application thereof. The structure of the compound is shown in formula I in the description. The application of the 3, 5-disubstituted hydantoin compound shown in the formula I or solvates, hydrates or salts of the compound in preparation of medicines for treating Alzheimer's disease, vascular dementia and other dementia diseases with memory impairment also belongs to the protection scope. Animal experiments prove that the compound has the effect of saving memory of animal models, has high safety, does not have mutagenicity, can stay in blood for several hours after oral administration and intravenous injection, and can enter the brain.
Control of 6-Exo and 7-Endo cyclizations of alkynylamides using platinum and bismuth catalysts
Girard, Anne-Lise,Enomoto, Taro,Yokouchi, Shinsuke,Tsukano, Chihiro,Takemoto, Yoshiji
supporting information, p. 1321 - 1324 (2013/01/11)
The rules of cyclization: Alkynylamides are regioselectively cycloisomerized into piperazin-2-one and 1,4-diazepan-2-one derivatives by using catalytic amounts of appropriate metal catalysts. A 6-exo-dig addition proceeds in the presence of Bi(OTf)3, while the 7-endo-dig addition occurs with PtCl2 for the same substrate. (see scheme; Ns=o- nitrobenzenesulfonyl, Ts=p-toluenesulfonyl, Cbz=benzyloxycarbonyl, DCE=dichloroethane) Copyright
Photophysical Properties of Tyrosine and Its Simple Derivatives Studied by Time-Resolved Fluorescence Spectroscopy, Global Analysis, and Theoretical Calculations
Guzow, Katarzyna,Ganzynkowicz, Robert,Rzeska, Alicja,Mrozek, Justyna,Szabelski, Mariusz,Karolczak, Jerzy,Liwo, Adam,Wiczk, Wies?aw
, p. 3879 - 3889 (2007/10/03)
The photophysical properties of tyrosine and its derivatives with free and blocked functional groups in water were studied by steady-state and time-resolved fluorescence spectroscopy and global analysis. Tyrosine fluorescence intensity decays in water at
Mechanism of fluorescence quenching of tyrosine derivatives by amide group
Wiczk, Wieslaw,Rzeska, Alicja,Lukomska, Joanna,Stachowiak, Krystyna,Karolczak, Jerzy,Malicka, Joanna,Lankiewicz, Leszek
, p. 99 - 106 (2007/10/03)
The difference between fluorescence lifetimes of the following amino acids: phenylalanine (Phe), tyrosine (Tyr), (O-methyl)tyrosine (Tyr(Me)), (3-hydroxy)tyrosine (Dopa), (3,4-dimethoxy)phenylalanine (Dopa(Me)2) and their amides was used to tes
