762172-77-0Relevant academic research and scientific papers
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty
Large, Jonathan M.,Birchall, Kristian,Bouloc, Nathalie S.,Merritt, Andy T.,Smiljanic-Hurley, Ela,Tsagris, Denise J.,Wheldon, Mary C.,Ansell, Keith H.,Coombs, Peter J.,Kettleborough, Catherine A.,Whalley, David,Stewart, Lindsay B.,Bowyer, Paul W.,Baker, David A.,Osborne, Simon A.
, (2019/08/30)
Focussed studies on imidazopyridine inhibitors of Plasmodium falciparum cyclic GMP-dependent protein kinase (PfPKG) have significantly advanced the series towards desirable in vitro property space. LLE-based approaches towards combining improvements in cell potency, key physicochemical parameters and structural novelty are described, and a structure-based design hypothesis relating to substituent regiochemistry has directed efforts towards key examples with well-balanced potency, ADME and kinase selectivity profiles.
Synthesis and biological activity of imidazopyridine anticoccidial agents: Part II
Scribner, Andrew,Dennis, Richard,Lee, Shuliang,Ouvry, Gilles,Perrey, David,Fisher, Michael,Wyvratt, Matthew,Leavitt, Penny,Liberator, Paul,Gurnett, Anne,Brown, Chris,Mathew, John,Thompson, Donald,Schmatz, Dennis,Biftu, Tesfaye
, p. 1123 - 1151 (2008/09/20)
Coccidiosis is the major cause of morbidity and mortality in the poultry industry. Protozoan parasites of the genus Eimeria invade the intestinal lining of the avian host causing tissue pathology, poor weight gain, and in some cases mortality. Resistance
