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Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, also known as 2'-deoxy-3'-O-(tert-butyldimethylsilyl)uridine, is a chemical compound derived from uridine, a nucleoside consisting of uracil and ribose. This modified version of uridine features a tert-butyldimethylsilyl (TBDMS) group attached to the 3'-hydroxyl group of the ribose sugar moiety. The TBDMS group is a protecting group commonly used in organic synthesis to shield hydroxyl groups from unwanted reactions. In Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, the TBDMS protection allows for selective modification or functionalization of the uridine molecule while preventing unwanted side reactions at the 3' position. This chemical is often used in the synthesis of oligonucleotides and other nucleic acid derivatives, as well as in the study of nucleic acid chemistry and structure.

76223-05-7

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76223-05-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 76223-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,2,2 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 76223-05:
(7*7)+(6*6)+(5*2)+(4*2)+(3*3)+(2*0)+(1*5)=117
117 % 10 = 7
So 76223-05-7 is a valid CAS Registry Number.

76223-05-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:76223-05-7 SDS

76223-05-7Relevant academic research and scientific papers

Protecting groups transfer: Unusual method of removal of tr and TBDMS groups by transetherification

Cabral, Nadia L. D.,Thiessen, Luciano Hoeltgebaum,Doboszewski, Bogdan

, p. 931 - 948 (2008)

The triphenylmethyl (Tr) group undergoes a transfer (transetherification or disproportionation) between the molecules of 5'-O-Tr-2'-deoxynucleosides in a process mediated by anhydrous sulfates of Cu+2, Fe+2, or Ni+2 to yield mixtures of 3',5'-bis-O-Tr and 3'-O-Tr products. If phenylmethanol is present in a reaction medium, detritylation results with concomitant formation of phenylmethyl triphenylmethyl ether. The behavior of t-butyldimethylsilyl (TBDMS) group in 5'-O-TBDMS-2'-deoxynucleosides is exactly the same. Such type of transetherifications was not observed before for the O-Tr and O-TBDMS groups. Copyright Taylor & Francis Group, LLC.

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