MAC-13243 is a pyrimidine derivative chemical compound that functions as a potent and selective inhibitor of the enzyme ABL1 and T315I-mutant ABL1. These enzymes are implicated in the development of certain types of leukemia and other cancers. MAC-13243 has demonstrated significant antiproliferative and antitumor activity in preclinical studies, positioning it as a potential therapeutic agent for drug-resistant cancer. Its capacity to target specific molecular pathways linked to cancer makes it a promising candidate for further development as a targeted therapy for both leukemia and solid tumors.
762239-61-2
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Basic information
- Product Name: MAC-13243
- Synonyms: MAC-13243;MAC-13243 (free base);4-[[(4-Chlorophenyl)methyl]thio]-1-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,6-tetrahydro-1,3,5-triazine;6-[(4-chlorophenyl)methylsulfanyl]-3-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dihydro-1H-1,3,5-triazine
- CAS NO:762239-61-2
- Molecular Formula: C20H24ClN3O2S
- Molecular Weight: 405.94
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: MAC-13243(CAS DataBase Reference)
- NIST Chemistry Reference: MAC-13243(762239-61-2)
- EPA Substance Registry System: MAC-13243(762239-61-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 762239-61-2(Hazardous Substances Data)
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762239-61-2 Usage
Uses
Used in Pharmaceutical Industry:MAC-13243 is used as an antiproliferative and antitumor agent for its potential in treating drug-resistant cancers. Its selectivity for inhibiting ABL1 and T315I-mutant ABL1 enzymes makes it a valuable asset in the development of targeted therapies for leukemia and other cancer types.
Used in Cancer Research:
In the field of cancer research, MAC-13243 is utilized to study the mechanisms of action and resistance associated with ABL1 and T315I-mutant ABL1 enzymes. This research is crucial for understanding the molecular pathways of cancer development and identifying potential therapeutic targets.
Used in Drug Development:
MAC-13243 is employed in the development of new drugs targeting specific molecular pathways in cancer cells. Its role in inhibiting key enzymes involved in cancer progression makes it a promising candidate for the creation of novel cancer treatments.
Used in Clinical Trials:
As a potential therapeutic agent, MAC-13243 is used in clinical trials to evaluate its safety, efficacy, and optimal dosage for the treatment of drug-resistant cancers, particularly leukemia and solid tumors.
Overall, MAC-13243's multifaceted applications across various sectors of the healthcare industry highlight its potential as a significant contributor to cancer research, drug development, and clinical treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 762239-61-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,2,2,3 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.Calculate Digit Verification of CAS Registry Number 762239-61:
(8*7)+(7*6)+(6*2)+(5*2)+(4*3)+(3*9)+(2*6)+(1*1)=172
172 % 10 = 2
So 762239-61-2 is a valid CAS Registry Number.
762239-61-2Upstream product
762239-61-2Downstream Products
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MAC-13243
