762241-03-2Relevant academic research and scientific papers
Synthesis of [1,2,4]triazolo[4,3-α]piperazines via highly reactive chloromethyloxadiazoles
Balsells, Jaume,DiMichele, Lisa,Liu, Jinchu,Kubryk, Michele,Hansen, Karl,Armstrong III, Joseph D.
, p. 1039 - 1042 (2007/10/03)
(Chemical Equation Presented) A concise, modular approach for the synthesis of [1,2,4]triazolo[4,3-α]piperazines via condensation of highly reactive chloromethyloxadiazoles with ethylenediamines is described. NMR studies of this reaction provide evidence that suggests a novel activation mechanism for electron-deficient chloromethyloxadiazoles.
PROCESS TO TETRAHYDROTRIAZOLOPYRAZINES AND INTERMEDIATES
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Page 13, (2010/02/08)
A novel process is provided for the preparation of substituted-5,6,7,8-tetrahydro[1,2,4]-triazolo[4,3-alpha]pyrazines which are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
