76226-32-9Relevant academic research and scientific papers
Switchable synthesis of cyclic carbamates by carbon dioxide fixation at atmospheric pressure
Toda, Yasunori,Shishido, Minoru,Aoki, Tatsuya,Sukegawa, Kimiya,Suga, Hiroyuki
supporting information, p. 6672 - 6675 (2021/07/13)
The base-promoted switchable synthesis of five- and six-membered cyclic carbamates using atmospheric pressure carbon dioxide as the C1 source was developed. The chemoselectivity of products was simply controlled by changing bases and solvents. The reaction proceeds effectively under mild conditions, affording valuable cyclic carbamates. Experimental results and DFT studies revealed the reaction mechanism.
Synthesis and application of Cu(II) immobilized MCM-41 based solid Lewis acid catalyst for aminolysis reaction under solvent-free condition
Chaudhary, Garima,Gupta, Neha,Singh, Amit Pratap
, (2021/07/22)
In this paper, a Cu(II) immobilized periodic mesoporous organosilica (PMOs) was synthesized and used as a reusable solid Lewis acid catalyst for the aminolysis of epoxides under solvent-free conditions. An amide-based ligand, L-propylsilyl (1) having a specific binding pocket was prepared and fabricated on mesoporous MCM-41 to produce mesoporous organosilica L-propylsilyl@MCM-41 (2). Further, it has been utilized for anchoring Cu(II) ions under controlled reaction conditions to yield solid Lewis acid catalyst Cu(II)-L-propylsilyl@MCM-41 (3). The synthesized catalyst 3 exhibits significantly higher catalytic activity for aminolysis compared to hitherto known solid Lewis acid catalysts. An extensive range of β-amino alcohols with high regio and stereoselectivity were prepared by using catalyst 3. The catalyst was recovered easily and reused eight times without any loss in its catalytic activity. Furthermore, the synthesis of clinically significant propranolol (β-blocker) from α- naphthyl glycidyl ether was attained successfully using catalyst 3 in a very decent yield.
Substituted piperazines as novel potential radioprotective agents
Cizkova, Jana,Filipova, Alzbeta,Havelek, Radim,Jelicova, Marcela,Koutova, Darja,Kucera, Tomas,Majorosova, Martina,Marek, Jan,Muckova, Lubica,Pejchal, Jaroslav,Prchal, Lukas,Psotka, Miroslav,Rezacova, Martina,Sinkorova, Zuzana,Tichy, Ales,Zivna, Natalie
supporting information, (2020/02/11)
The increasing risk of radiation exposure underlines the need for novel radioprotective agents. Hence, a series of novel 1-(2-hydroxyethyl)piperazine derivatives were designed and synthesized. Some of the compounds protected human cells against radiation-
X-ray structurally characterized Mo (VI), Fe (III) and Cu (II) complexes of amide-imine conjugate: (bio)catalytic and histidine recognition studies
Ta, Sabyasachi,Ghosh, Milan,Salam, Noor,Das, Jayanta,Islam, Manirul,Brand?o, Paula,Félix, Vítor,Sanmartin, Jesus,Das, Debasis
, (2020/07/13)
An amide-imine conjugate, (E)-N′-((2-hydroxybenzen-1-yl) methylene)-4-methylbenzohydrazide (H2LPTASAL), derived from 4-methyl-benzoic acid hydrazide (PTA) and 2-hydroxybenzaldehyde is used to prepare Mo (VI), Cu (II) and Fe (III) complexes. The X-ray structurally characterized complexes have been explored as catalyst for amine assisted asymmetric ring opening (ARO) of epoxide, carbon-heteroatom cross-coupling and ethyl benzene oxidation. In addition, their catecholase like activities have thoroughly been investigated. Moreover, the Cu (II) complex selectively recognizes histidine by fluorescence spectroscopy.
Enzyme- and ruthenium-catalyzed dynamic kinetic resolution involving cascade alkoxycarbonylations for asymmetric synthesis of 5-Substituted N-Aryloxazolidinones
Zhang, Yang,Xie, Sheng,Yan, Mingdi,Ramstr?m, Olof
, p. 138 - 144 (2019/04/10)
Asymmetric synthesis of N-aryloxazolidinones via dynamic kinetic resolution was developed. A ruthenium-based catalyst was used in the racemization of β-anilino alcohols, while Candida antarctica lipase B (CAL-B) was applied for two selective alkoxycarbony
Catalytic synthesis of organic cyclic carbonate through CO2 fixation and production of β-amino alcohol via ring opening of epoxides under green condition by polystyrene embedded Al(III) catalyst
Biswas, Surajit,Roy, Dipanwita,Ghosh, Swarbhanu,Islam, Sk Manirul
, (2019/08/06)
Development of low cost, eco-friendly heterogeneous catalyst for the production of value added organic compounds has been drawn a considerable attention to the synthetic chemists in recent era. Keeping the above idea in our mind, we have design and synthesized a polymer anchored Al(III) composite from modified Merrifield resin. The composite was characterized properly by FT-IR spectra, SEM, EDAX, elemental analysis, ICP-AES and PXRD studies. The low cost material is very efficient heterogeneous catalyst for the production of fine organic chemicals such as organic cyclic carbonates and 2-amino alcohols under green and mild reaction conditions. Organic cyclic carbonates were synthesized through the insertion of carbon dioxide into epoxides at room temperature under solvent free condition. The developed protocol of catalytic synthesis of cyclic carbonates is sustainable, eco-friendly and cost-effective. Moreover atmospheric carbon dioxide is utilized here. Besides, the catalyst is very much efficient to produce 2-amino alcohol from ring opening of epoxides by nucleophilic attack of amine under solvent free condition and at room temperature. This polymer anchored Al(III) can be recovered and reused easily. The catalyst preserved its catalytic intensity even after use of eight successive catalytic cycles.
Stereocontrolled, Divergent, Al(lll)-Catalyzed Coupling of Chiral N-Aryl Epoxy Amines and CO2
Lee, Yuseop,Choi, Jonghoon,Kim, Hyunwoo
supporting information, p. 5036 - 5039 (2018/08/24)
A divergent coupling reaction was achieved between N-aryl epoxy amines and CO2. By using two different cocatalysts, tetrabutylammonium iodide (TBAI) or 4-dimethylaminopyridine (DMAP) together with an Al(III) Lewis acid, cyclic carbonates or oxazolidinones were selectively produced through two distinct reaction pathways, respectively. The proposed reaction mechanism was supported by the stereochemical determination of the products. A gram-scale production of Linezolid was successfully achieved.
Zirconium triflate grafted on SBA-15 as a highly efficient solid acid catalyst for ring opening of epoxides by amines and alcohols
Tayade, Kamlesh N.,Wang, Lianyue,Shang, Sensen,Dai, Wen,Mishra, Manish,Gao, Shuang
, p. 758 - 766 (2017/04/24)
Metal (Al, Ti, Zr) triflate grafted mesoporous SBA-15 (AlTf/S, TiTf/S, ZrTf/S) samples were synthesized as inexpensive solid acid materials by a simple one-pot-two-step synthesis methodology. These materials were characterized by X-ray diffraction, N2-sorption, thermogravimetric analysis, Fourier transform infrared spectroscopy (FT-IR), in-situ pyridine FT-IR spectroscopy, and elemental analysis. ZrTf/S was found to be a highly efficient and reusable solid acid catalyst for ring opening of epoxides with amines and alcohols and produced β-amino alcohols and β-alkoxy alcohols respectively under ambient reaction conditions. The ZrTf/S catalyst showed the highest activity, which was attributed to its high acidity compared with that of the Ti and Al containing samples.
An efficient method for regioselective ring opening of epoxides by amines under microwave irradiation using Bi(NO3)3·5H2O as a catalyst
Bansal, Shobha,Kumar, Yogendra,Pippal, Parveen,Das, Dipak K.,Pramanik, Panchanan,Singh, Prabal P.
, p. 2668 - 2671 (2017/04/03)
Bismuth(iii)nitrate pentahydrate, a highly efficient environmentally benign catalyst, is used for the nucleophilic ring opening of epichlorohydrin and styrene oxide with aromatic, aliphatic and heteroaromatic amines under solvent free microwave conditions
Greener aminolysis of epoxides on BiCl3/SiO2
Mohsenzadeh, Farshid,Aghapoor, Kioumars,Darabi, Hossein Reza,Jalali, Mohammad Reza,Halvagar, Mohammad Reza
, p. 978 - 985 (2016/08/08)
The remarkable catalytic activity of BiCl3/SiO2 for the ring-opening of epoxides with aromatic and aliphatic amines under microwave and thermal heating was observed. This eco-friendly heterogeneous catalyst displayed high to excellent regioselectivity in the synthesis of β-amino alcohols under solvent-free conditions. High turnover frequency (TOF) values under microwave heating and excellent reusability of the catalyst may significantly contribute to applied chemistry.
