762272-97-9

Upstream product

• 165896-48-0 2-[3-(3-bromo-phenyl)-3-oxo-propyl]-benzoic acid methyl ester 
• 762272-95-7 2-[3-(3-bromophenyl)-3-hydroxypropyl]benzoic acid methyl ester 
• 762272-99-1 (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol 

Downstream Products

• 762272-99-1 (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol 
• 1258428-71-5 trans-1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one 
• 762273-01-8 (S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol 
• 287930-77-2 (S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol 

Relevant academic research and scientific papers

For the synthesis of montelukast intermediate compound and its preparation method

The invention relates to a pharmaceutical intermediate and a preparation method thereof, and especially relates to an intermediate compound represented by the formula (1) for synthesizing montelukast; wherein in the formula the X' represents a halogen ele

The palladium-catalyzed aerobic kinetic resolution of secondary alcohols: Reaction development, scope, and applications

The first palladium-catalyzed enantioselective oxidation of secondary alcohols has been developed, utilizing the readily available diamine (-)-sparteine as a chiral ligand and molecular oxygen as the stoichiometric oxidant. Mechanistic insights regarding the role of the base and hydrogen-bond donors have resulted in several improvements to the original system. Namely, addition of cesium carbonate and tert-butyl alcohol greatly enhances reaction rates, promoting rapid resolutions. The use of chloroform as solvent allows the use of ambient air as the terminal oxidant at 23°C, resulting in enhanced catalyst selectivity. These improved reaction conditions have permitted the successful kinetic resolution of benzylic, allylic, and cyclopropyl secondary alcohols to high enantiomeric excess with good-toexcellent selectivity factors. This catalyst system has also been applied to the desymmetrization of meso-diols, providing high yields of enantioenriched hydroxyketones.

The resolution of important pharmaceutical building blocks by palladium-catalyzed aerobic oxidation of secondary alcohols

The palladium-catalyzed aerobic oxidative kinetic resolution of key pharmaceutical building blocks is described. Substrates investigated are relevant to the enantioselective preparation of Prozac, Singulair, and the promising hNK-1 receptor antagonist from Merck. The latter provides the most selective aerobic oxidative kinetic resolution yet described.