762285-44-9

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 762285-43-8 [(S)-1-((S)-Methyl-pyrrolidin-3-yl-carbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester 
• 762285-42-7 {(S)-1-[((S)-1-Benzyl-pyrrolidin-3-yl)-methyl-carbamoyl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester 

Downstream Products

• 848464-88-0 (S)-3-(5-Bromo-1-oxo-1,3-dihydro-isoindol-2-yl)-pyrrolidine-1-carboxylic acid methyl-[(S)-1-(3-phenyl-propyl)-pyrrolidin-3-yl]-amide 
• 762285-45-0 (S)-3-Amino-pyrrolidine-1-carboxylic acid methyl-[(S)-1-(3-phenyl-propyl)-pyrrolidin-3-yl]-amide 

Relevant academic research and scientific papers

Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists

Ureas derived from two substituted 3-aminopyrrolidine subunits were prepared as constrained analogs of a linear lead compound and tested as antagonists of the MCH1 receptor. The series was optimized for substitution and stereochemistry to generate a functional antagonist with a Ki of 3.3 nM and IC50 of 12 nM (GTPγS).