76241-77-5

Usage

Chemical class

Cyclic ether, dioxanes

Common uses

a. Solvent in industrial processes
b. Component in consumer products

Health hazards

a. Potential human carcinogen
b. Respiratory irritation
c. Skin sensitization
d. Central nervous system depression

Safety precautions

Handle and use with care to minimize risks associated with its use.

Upstream product

• 2043-61-0 cyclohexanecarbaldehyde 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 1003852-79-6 3-(1-cyclohexylprop-2-ynyloxy)propan-1-ol 
• 17773-49-8 3-hydroxypropyl cyclohexanecarboxylate 
• 136611-33-1 (2R,3S,4S)-4-<(t-butyldiphenylsilyl)oxy>-2-(cyclohexyl-<(3-hydroxypropyl)oxy>methyl)-3-methyl-3-vinylcyclohexanone 

Relevant academic research and scientific papers

Visible-light-induced acetalization of aldehydes with alcohols

In this work, we have achieved a simple and general method for acetalization of aldehydes by means of a photochemical reaction under low-energy visible light irradiation. A broad range of aromatic, heteroaromatic, and aliphatic aldehydes have been protected under neutral conditions in good to excellent yields using a catalytic amount of Eosin Y as the photocatalyst. Our visible light mediated acetalization strategies are successful for more challenging acid-sensitive aldehydes and sterically hindered aldehydes. Notably, this protocol is chemoselective to aldehydes, while ketones remain intact.

Acetonyltriphenylphosphonium bromide and its polymer-supported analogues as catalysts for the protection of carbonyl compounds as acetals or thioacetals

Both acetonyltriphenylphosphonium bromide (ATPB) and poly-p-styryldiphenylacetonylphosphonium bromide (PATPB) are excellent catalysts in the protection of aldehydes as acetals or thioacetals. In general, ATPB is highly selective as ketones do not give good yields of ketals with this catalyst.

An efficient procedure for the preparation of cyclic ketals and thioketals catalyzed by zirconium sulfophenyl phosphonate

A convenient method for the preparation of cyclic ketals and thioketals using zirconium sulfophenyl phosphonate as catalyst is described.

AN EFFICIENT SbCl3-METAL SYSTEM FOR ALLYLATION, REDUCTION AND ACETALIZATION OF ALDEHYDES

SbCl3-Fe or SbCl3-Al could induce allylation of aldehydes with allylic halides at room temperature to give high yields of the corresponding homoallylic alcohols with high regio- and chemoselectivity.SbCl3-Al or SbCl3-Zn in DMF-H2O was found to be an efficient reduction system for conversion of aldehydes to alcohols at room temperature in excellent yields.While alcohol was used as solvent instead of DMF-H2O, the acetalization product was obtained in almost quantitative yield.Catalytic amount of SbCl3 was effective for this purpose.This acetalization method could also be applied to ketone.