76257-73-3Relevant academic research and scientific papers
Convenient Reductive Methylation of Amines with Carbonates at Room Temperature
Li, Yuehui,Sorribes, Iván,Vicent, Cristian,Junge, Kathrin,Beller, Matthias
, p. 16759 - 16763 (2015/11/16)
Methylation of amines is a fundamental and commonly used reaction in organic synthesis. Many methods are known including various reductive methylations using formaldehyde, formic acid, or carbon dioxide in the presence of reductants. However, several of these methods suffer from limited substrate scope and chemoselectivity because of the different nucleophilicities of substrates. In this respect, the combination of carbonates and hydrosilanes is a valuable methylation source in the presence of Pt-based catalysts. This highly tunable method allows for methylation of both aromatic and aliphatic amines, and chemoselective methylation of aminoalcohols and diamines. Notably, the in situ-formed catalyst can also be used for the reduction of carbonates to methanol at room temperature. Mechanistic insights on intermediates formed during the reaction pathway were obtained by using ESI mass spectrometry.
Process for the synthesis of N-methyl-dialkylamines from secundary amines and formaldehyde
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Page column 6, (2008/06/13)
Production of N-methyldialkylamines comprises reacting a dialkylamine with 1.5-3 molar equivalents of formaldehyde at 100-200[deg]C; degassing the reaction product; separating the aqueous phase; and distilling the organic phase.
NOUVELLE METHODE DE PREPARATION D'AMINES TERTIAIRES
Kapnang, H.,Charles, G.
, p. 1597 - 1600 (2007/10/02)
Tertiary amines R-N(CH2R')2 are obtained by reacting 1,5,3-perhydrodioxazepines derivatived from primary amines RNH2, with Grignard reagents R'MgX.
