76273-51-3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 23451-96-9 2-amino-5-methylthiophenol 
• 67434-68-8 Ethyl acetoacetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 106-49-0 p-toluidine 
• 31183-91-2 2-[(2-amino-5-methylphenyl)dithio]-4-methylphenylamine 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 

Downstream Products

• 169058-64-4 C₁₈H₁₆N₄S₂ 
• 169058-65-5 C₁₈H₁₅ClN₄S₂ 
• 169058-66-6 C₁₈H₁₅BrN₄S₂ 
• 169058-67-7 C₁₉H₁₈N₄S₂ 
• 169058-68-8 C₁₉H₁₈N₄OS₂ 
• 169058-83-7 C₁₈H₁₅BrN₄OS 
• 169058-82-6 C₁₈H₁₅ClN₄OS 
• 169058-81-5 C₁₈H₁₆N₄OS 
• 169059-17-0 C₁₉H₂₀N₄O₂S₂ 
• 169059-16-9 C₁₉H₂₀N₄OS₂ 
• 169059-15-8 C₁₈H₁₇BrN₄OS₂ 
• 169059-14-7 C₁₈H₁₇ClN₄OS₂ 
• 169059-13-6 C₁₈H₁₈N₄OS₂ 

Relevant academic research and scientific papers

Novel synthesis of 1,4-benzothiazines in water accelerated by β-cyclodextrin

Novel one-pot synthetic protocol has been developed for obtaining 2, 3-disubstituted 1,4-benzothiazines with excellent yields, carrying cyclocondensation of 1,3-dicarbonyl compounds with substituted 2-(2-(2-aminophenyl)disulfanyl)benzenamines, under supra

A facile and green synthesis of "5-(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl)-4-aryl-4H-1, 2, 4-triazole-3-thiols" under ultrasound irradiation

A series of novel 3-methyl-7-substituted-4H-1, 4-benzothiazine-2- carbohydrazide & corresponding thiosemicarbazide have been synthesized. The 1, 4-benzothiazine thiosemicarbazides i.e. 2-[(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl) carbonyl]-N-aryl-hydrazine carbothiamide when cyclised with 2N sodium hydroxide via intramolecular dehydrative cyclisation gave benzothiazonyl triazoles. The given procedure is in 4-steps. The final step is an intramolecular cyclisation is achieved by ultrasound irradiation & also by conventional method. In general, substantial improvement in rates and increase in modest yields observed when reactions are carried out under sonication, compared with classical heating method. The structures of these compounds have been elucidated by spectral (IR, 1H NMR) analysis.

Synthesis and antimicrobial activity of some new 1, 4-benzothiazine containing thiosemicarbazides and 1, 3, 4-oxadiazole derivatives

A series of novel 3- methyl-7-substituted-4H-1,4-benzothiazine-2- carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted- 4H -1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H- 1,4-benzothiazin-2-yl)- N -aryl- 1,3,4- oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms.

Synthesis and antimicrobial activity of morpholinyl/ piperazinylbenzothiazines

Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with b-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.

Facile synthesis of bioactive 4H-[1,4]-benzothiazines under solvent free conditions

An efficient method for synthesis of 4H-[1,4]-benzothiazines under solvent free conditions has been developed. The oxidative condensation of 2-aminobenzenethiols with β-diketones/β-ketoesters in presence of catalytic amount of hydrazine hydrate yields the 4H-[1,4]-benzothiazines. The reaction is accelerated by microwave irradiation under solvent free conditions in presence of an energy transfer agent DMF to get the product in high yield. The 2-aminobenzenethiazole required for the synthesis of 4H-[1,4]-benzothiazines are also obtained by a new method instead of presently used time consuming and low yielding method. The structure of the synthesized compounds has been characterized by IR, NMR, mass spectral studies and elemental analysis.

Baker's yeast catalyzed synthesis of 1,4-benzothiazines, performed under ultrasonication

An efficient and simple one pot method has been developed for the synthesis of 1,4-benzothiazines by allowing the condensation of 2-aminobenzenethiols and 1,3-dicarbonyls using cheaper biocatalyst, baker's yeast. The role of ultrasonication in the rate expediting of the condensation has been discussed.

Synthesis of a series of 2,3-disubstituted 4H-1,4-benzothiazines and X-ray crystal structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate

The reaction between 2-aminobenzenethiol and ethyl acetoacetate is studied under a variety of conditions, and a procedure for the exclusive synthesis of 1,4-benzothiazines by the neat reaction of substituted aminothiols with β-ketoesters and β-dicarbonyl compounds in 85-96% yield is described. With microwave heating, even when both the reactants are solid, yields are high, reaction times brief, and work-up easy. A facile reaction is also observed even in a solid-state reaction. The molecular structure of ethyl 7-chloro-3-methyl-4H-1,4-benzothiazine-2-carboxylate (4d) was determined by single-crystal X-ray diffraction.

Dry media synthesis of 4H-1, 4-benzothiazines under microwave irradiation using basic alumina as solid support

A simple and efficient method has been developed for the rapid synthesis of substituted 4H-1, 4-benzothiazines (3) from 2-aminobenzenethiols (1) and β-ketoester/ β-diketones (2) in dry media under microwave irradiation using basic alumina as solid support.

A CONVENIENT AND SINGLE STEP SYNTHESIS OF SUBSTITUTED 4H-BENZOTHIAZINES.

A simple one step synthesis is reported for substituted 4H-benzothiazines involving the condensation of 5-(chloro, bromo, methyl, methoxy, ethoxy)-, 4-methyl- and 3-(chloro and methoxy)-2-aminobenzenethiols with acetylacetone/ethyl acetoacetate/dibenzoylmethane in DMSO.