76274-94-7

Basic information

• Product Name: 4-cyclopropylbenzenecarboxylic acid chloride
• Synonyms: 4-cyclopropylbenzenecarboxylic acid chloride;4-CYCLOPROPYLBENZOYL CHLORIDE
• CAS NO: 76274-94-7
• Molecular Formula: C₁₀H₉ClO
• Molecular Weight: 180.63086
• Mol File: 76274-94-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-cyclopropylbenzenecarboxylic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyclopropylbenzenecarboxylic acid chloride(76274-94-7)
• EPA Substance Registry System: 4-cyclopropylbenzenecarboxylic acid chloride(76274-94-7)

Safety Data

• Hazardous Substances Data: 76274-94-7(Hazardous Substances Data)

Upstream product

• 1798-82-9 4-cyclopropylbenzoic acid 

Downstream Products

• 121193-12-2 N,N-dimethyl-4-cyclopropylbenzamide 
• 1198088-28-6 4-(2-guanidinothiazol-4-yl)phenyl 4-cyclopropylbenzoate hydrobromide 
• 1198088-27-5 4-(2-bromoacetyl)phenyl 4-cyclopropylbenzoate 
• 1418127-82-8 C₃₀H₂₉FN₆O₂ 
• 121193-04-2 [5-(4-Cyclopropyl-benzoyl)-1-methyl-4-methylsulfanyl-1H-pyrrol-2-yl]-acetic acid ethyl ester 
• 35391-85-6 4-cyclopropyl-benzoic acid ethyl ester 
• 1198088-26-4 4-acetylphenyl 4-cyclopropylbenzoate 
• 89542-04-1 methyl 5-(4-cyclopropylbenzoyl)-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate 

Relevant articles and documents

Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation

Bruton's tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen receptor signaling in B cells and of Fc receptor signaling in mast cells and macrophages. A BTK

MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS

Novel myosin light chain phosphatase inhibitors, compositions containing them, methods of making and using them, and methods of using fluorescent myosin light chain phosphatase inhibitors are described.

Carbon-13 Nuclear Maagnetic Resonance Spectroscopy. Substituent-induced Chemical Shift Effects on Cyclopropyl Carbons of 4-Substituted Cyclopropylbenzenes

Carbon-13 chemical shifts of the cyclopropyl carbons of eleven 4-substituted cyclopropylbenzenes have been measured under conditions effectively corresponding to infinite dilution in DCCl3.The substituent-induced chemical shifts (SCS) of both the α and β carbons of the cyclopropane ring were found to be downfield with electron-attracting groups and upfield for electron-donating groups.The trends for the β carbons correspond to those observed for the β carbons of 4-substituted phenylethenes, while the trends of the α carbons are similar to those found for the α carbons of 4-substituted isopropyl benzenes.The results for the β carbons can be rationalized by postulating a substantial contribution from a hyperconjugative resonance effect involving the ? system of the benzene ring (and its 4-substituent) and C-α--C-β bonds of the cyclopropane ring.The effects on the α carbons are in accord with a very resonable smaller inductive polarization of the C-α--C-β bonds than encountered for the carbons of corresponding ethenyl- or ethynylbenzenes.