76279-32-8

Usage

Uses

Used in Pharmaceutical Industry:
Benzenemethanamine, 2,6-dimethoxy-α-methyl-, (S)(9CI) is used as a research chemical for studying its potential therapeutic effects in treating conditions such as depression, anxiety, and addiction. Its interaction with the serotonin system in the brain makes it a promising candidate for further research and development in the field of psychopharmacology.
Used in Neuroscientific Research:
Benzenemethanamine, 2,6-dimethoxy-α-methyl-, (S)(9CI) is utilized in neuroscientific research to understand its effects on the serotonin system and to explore its potential in developing new treatments for neurological and psychiatric disorders.

Upstream product

• 2040-04-2 2,6-dimethoxyacetophenone 
• 122078-20-0 (1S,1'S)-N-(1'-phenylethyl)-1-(2'',6''-dimethoxyphenyl)ethylamine 

Downstream Products

• 128114-00-1 N-[(S)-1-(2,6-Dimethoxy-phenyl)-ethyl]-N-(2,4-dinitro-phenylsulfanyl)-4-methyl-benzenesulfonamide 
• 138474-79-0 (1S)-N-tert-butoxycarbonyl-1-(2,6-dimethoxyphenyl)ethylamine 

Relevant academic research and scientific papers

Chiral Building Blocks for the Synthesis of Nitrogen-Containing Natural Products, 5. The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones

An efficient two-step procedure for the synthesis of enantiomerically pure, benzene nucleus-substituted 1-phenylethylamines 1 is described, with predictable absolute configuration at the stereogenic center: Imine formation from the substituted acetophenones 6 with (S)- or (R)-1-phenylethylamine and subsequent hydrogenation of the resulting Schiff bases 8 over Raney nickel leads to the secondary amines 9 and 10 in high diastereoselectivities.These dibenzylamines are cleaved regioselectively, usually next to the less substituted aromatic ring, giving the desired chiral 1-phenylethylamines 1 in high yields and enantiomeric purities.Scope and limitations of this new and facile approach to the versatile building blocks 1 are reported.