76284-94-1Relevant academic research and scientific papers
Synthesis and antiproliferative activity of cyano and amidino substituted 2-phenylbenzothiazoles
Racane, Livio,Tralic-Kulenovic, Vesna,Kitson, Richard P.,Karminski-Zamola, Grace
, p. 1571 - 1577 (2006)
Series of cyano, dicyano, amidino, and diamidino substituted 2-phenylbenzothiazoles were prepared. Mono- and dicyano substituted benzothiazoles were obtained by condensation of appropriate substituted benzaldehydes with 2-aminothiophenol or 4-amino-3-mercaptobenzonitrile. The appropriate amidines or diamidines were prepared by Pinner reaction. The compounds were tested against breast, prostate, and lung cancer cell lines in a 72∈h cytotoxicity assay. Many of the compounds had at 10∈μM activity equivalent to 2-(4-aminophenyl)benzothiazole, while four compounds had significantly better activity, particularly in the breast cancer model. Springer-Verlag 2006.
