76286-86-7

Upstream product

• 110-89-4 piperidine 
• 76286-84-5 1,8-dimethyl-2-phenyl-6H-imidazo<1,2-f>xanthine 
• 91028-86-3 1,8-Dimethyl-7-phenyl-2-N-piperidinoimidazo<1,2-f>purin-4-one 
• 91028-85-2 1,8-Dimethyl-7-phenyl-2-chloroimidazo<1,2-f>purine-4-one 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVES OF PURINES. 5. NUCLEOPHILIC SUBSTITUTION IN SERIES OF IMIDAZOPURINE DERIVATIVES

The chlorination of 1,8-dimethyl-7-phenylimidazoxanthine with an equimolar amount of PCl5 in POCl3 leads to 2,4-dichloro-8-methyl-7-phenylimidazopurine.The possibility of substitution of the halogen atoms in reactions with nucleophilic reage

HETEROCYCLIC DERIVATIVES OF PURINES. 3. SYNTHESIS AND MASS SPECTROMETRIC STUDY OF IMIDAZOPURINE

A mixture containing 65percent 1-methyl-2-phenyl-5,7-dichloro- and 35percent 1-methyl-2-phenyl-3,5,7-trichloroimidazopurine (the percentages of the components were established by means of chromatographic mass-spectrometric analysis) was obtained by refluxing 1,8-dimethyl-2-phenylimidazoxanthine in POCl3 in the presence of excess PCl5.Reduction of this mixture with concentrated HCl in the presence of red phosphorus leads to 1-methyl-2-phenylimidazopurine, while heating with piperidine gives a mixture consisting of 55percent 1-methyl-2-phenyl-6-piperidino-8-chloroimidazopurine and 45percent 1-methyl-2-phenyl-3,8-dichloro-6-piperidinoimidazopurine.The IR, PMR, and mass spectra of the compounds obtained are discussed.