76287-60-0Relevant academic research and scientific papers
Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720
Lu, Xuequan,Sun, Chaode,Valentine, William J.,Shuyu,Liu, Jianxiong,Tigyi, Gabor,Bittman, Robert
supporting information; experimental part, p. 3192 - 3195 (2009/09/30)
The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)- vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial ce
Preparation and Properties of Tertiary p-Alkylarylphosphines containing Straight-chain Alkyl Groups
Franks, Stephen,Hartley, Frank R.
, p. 2233 - 2237 (2007/10/02)
A series of tris(p-alkylaryl)phosphines with straight-chain alkyl groups, P(p-C6H4-CnH2n+1)3 where n=2-9, have been prepared by reaction of phosphorus trichloride with the Grignard reagent derived from the corresponding p-bromoalkylbenzene.When n=2 and 3 the phosphines are crystalline solids, but for n>3 they are viscous oils up to n=9, which is a waxy solid.The phosphines have been characterised by microanalysis, and i.r., 1H and 31P n.m.r., and mass spectrometry.The p-substituted-arylphosphines are more sensitive than triphenylphosphine to air; aerial oxidation converts them exclusively into the corresponding phosphine oxides, in contrast to trialkylphosphines which are oxidised to a complex mixture of products.The complexing ability of the new phosphines (PAr3) is demonstrated by their ready displacement of 1,5-cyclo-octadiene (cod) from (M=Pd and Pt) to yield trans- and cis-, respectively.
