76287-92-8Relevant academic research and scientific papers
Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B
Meleddu, Rita,Distinto, Simona,Cirilli, Roberto,Alcaro, Stefano,Yanez, Matilde,Sanna, Maria Luisa,Corona, Angela,Melis, Claudia,Bianco, Giulia,Matyus, Peter,Cottiglia, Filippo,Maccioni, Elias
, p. 264 - 270 (2017)
3,5-Diaryl-4,5-dihydroisoxazoles were synthesized and evaluated as monoamine oxidase (MAO) enzyme inhibitors and iron chelators. All compounds exhibited selective inhibitory activity towards the B isoform of MAO in the nanomolar concentration range. The b
A Novel NO Insertion into Cyclopropane Ring by Use of NOBF4. Formation of 2-Isoxazolines
Ichinose, Nobuyuki,Mizuno, Kazuhiko,Tamai, Toshiyuki,Otsuji, Yoshio
, p. 233 - 236 (2007/10/02)
The reaction of 1,2-diarylcyclopropanes with NOBF4 in CH3CN gave 3,5-diaryl-2-isoxazolines in good yields.For unsymmetrically substituted cyclopropanes, the mixtures of two isomeric isoxazolines were obtained.The mechanism and regioselectivety in this NO
Synthesis of New Isoxazoles from Isoxazolines, Chalkones, Chalkone Dibromides, Epoxides and Acetylated Ketoximes and Their Conversion into Novel Heterocycles
Elkasaby, M. A.,Salem, M. A. I.
, p. 571 - 575 (2007/10/02)
A convenient and easy conversion of 2-isoxazolines (II) to isoxazoles (V) via N-bromosuccinimide bromination and subsequent dehydrobromination with bases is described.The isoxazoles have also been synthesized from chalkones (I), chalkone dibromides (III)
