7629-50-7

Basic information

• Product Name: (6R)-3-hydroxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid
• CAS NO: 7629-50-7
• Molecular Weight: 348.379
• Mol File: 7629-50-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (6R)-3-hydroxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (6R)-3-hydroxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid(7629-50-7)
• EPA Substance Registry System: (6R)-3-hydroxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid(7629-50-7)

Safety Data

• Hazardous Substances Data: 7629-50-7(Hazardous Substances Data)

Upstream product

• 859-07-4 cephaloram 
• 805-64-1 (6R)-3-acetoxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 
• 108260-00-0 7-aminocephalosporanic acid 
• 859-07-4 cefaloram 
• 879661-66-2 (6R)-3-acetoxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 473988-41-9 allyl 3-hydroxymethyl-7-phenylacetamido-3-cephem-2-carboxylate 
• 473988-42-0 2-(allyloxy)carbonyl-7-phenylacetamido-3-cephem-3-methyl 3-(2-chloroethyl)-4-oxo-imidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate 
• 473988-51-1 (6R,7R)-2-(allyloxy)carbonyl-7-phenylacetamido-3-cephem-3-methyl 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-8-carboxylate 
• 851-59-2 lactone of 7-phenylacetamidocephalosporanic acid 
• 7629-27-8 (6R)-3-butyryloxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 
• 855-80-1 (6R)-3-hydroxymethyl-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid methyl ester 
• 131580-87-5 7-Amino-3-(1-chlorethenyl)-3-cephem-4-carbonsaeurebenzhydrylester-hydrochlorid 
• 133378-61-7 7-<<(2-Amino4-thiazolyl)(methoxyimino)acetyl>amino>-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester 
• 131580-85-3 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester-1-oxid 
• 131580-86-4 7-Phenylacetamido-3-(1-chlorethenyl)-3-cephem-4-carbonsaeure-benzhydrylester 
• 131580-84-2 7-Phenylacetamido-3-(1-chlorethenyl)-2-cephem-4-carbonsaeure-benzhydrylester 
• 113139-54-1 diphenylmethyl 7-phenylacetamido-3-acetyl-2-cephem-4-carboxylate 
• 39914-26-6 3-formyl-7β-phenylacetylamino-ceph-2-em-4α-carboxylic acid diphenylmethyl ester 

Relevant articles and documents

Synthesis and antibacterial activity of dual-action agents of a β-lactam antibiotic with cytotoxic agent mitozolomide or temozolomide

Dual-action agents 5a-f and 12a-f, a β-lactam antibiotic combined with a cytotoxic agent, mitozolomide (Meto) or temozolomide (Temo), were synthesised. The antibacterial activity (MICs) of the dual-action agents has been determined against a panel of bacteria including several β-lactamase producing strains. The tests showed 5a-f active against the non-β-lactamase producing methicillin sensitive Staphylococcus aureus (MSSA) strains, however, little synergistic effect between the β-lactam and the cytotoxic agent was observed. 12a-f demonstrated some synergistic effect against bacteria. 12a, in particular, is active against ampicillin resistant (β-lactamase-producing) strains of Serratia marcescens.