76290-93-2

Basic information

• Product Name: 7-Methoxy-6--1-tetralol
• CAS NO: 76290-93-2
• Molecular Weight: 340.376
• Mol File: 76290-93-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 7-Methoxy-6--1-tetralol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxy-6--1-tetralol(76290-93-2)
• EPA Substance Registry System: 7-Methoxy-6--1-tetralol(76290-93-2)

Safety Data

• Hazardous Substances Data: 76290-93-2(Hazardous Substances Data)

Upstream product

• 131-11-3 phthalic acid dimethyl ester 
• 6836-19-7 7-Methoxy-1-tetralone 

Relevant articles and documents

Arene-Metal Complex in Organic Synthesis: Directed Regioselective Lithiation of (?-Substituted benzene)chromium Tricarbonyl Complexes

(3-Methoxybenzyl alcohol)chromium tricarbonyl complex (8) and (2-substituted 7-methoxy-1-tetralol)chromium complexes 14-17 are selectively lithiated at the 4-position and 6-position, respectively, by treatment with n-BuLi/TMEDA.The regioselectivity of this lithiation is improved with increasing bulk of the butyllithium reagent employed.Since the direct lithiation of the corresponding chromium-free arenes normally proceeds at the 2- and 8-positions, complementarily substituted arenes can be prepared by using chromium tricarbonyl complexes.The different lithiation is explained by the relative configuration of the chromium tricarbonyl group in the (?-arene)Cr(CO)3 complexes and the electrostatic factor.This rationalization is supported, at least in part, by X-ray crystallography of the complex 16.On the other hand, the chromium complexes of arenes without a free hydroxyl group, such as benzyl methyl ether or ethylene acetals of benzaldehydes, are lithiated at the 2-position preferentially.