76292-77-8

Upstream product

• 6829-40-9 aminomalonic acid diethyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 20538-21-0 α,α-diphenylindole-2-methanol 

Downstream Products

• 1219811-90-1 diethyl 3-(4-nitrophenyl)-4,9-dioxo-2,3,3a,4-tetrahydro-1H-benzo[f]isoindole-1,1(9H,9aH)-dicarboxylate 

Relevant academic research and scientific papers

Catalytic Asymmetric [3+3] Cycloaddition of Azomethine Ylides with C3-Substituted 2-Indolylmethanols

The first catalytic asymmetric [3+3] cycloaddition of azomethine ylides with C3-substituted 2-indolylmethanols has been established, leading to diastereo- and enantioselective construction of a tetrahydropyrimido[1,6-a]indole framework (up to 91% yield, >

Axially Chiral Cyclic Phosphoric Acid Enabled Enantioselective Sequential Additions

Efficient axially chiral cyclic phosphoric acid catalyzed enantioselective sequential additions of 2-aryl-3H-indol-3-ones, aldehydes, and diethyl 2-aminomalonate have been developed, and a new type of nitrogen-containing heterocyclic compounds, 2,3-dihydro-1H-imidazo[1,5-a]indol-9(9aH)-one derivatives, were prepared in good yields and excellent ee values with a wide functional group tolerance, in which the reactivity and enantioselectivity of the substrates were enabled by our newly developed axially chiral cyclic phosphoric acid, (R)-CYC-9-CPA. Furthermore, the corresponding 1H-imidazo[1,5-a]indol-9(9aH)-ones were constructed through the easy oxidation of 2,3-dihydro-1H-imidazo[1,5-a]indol-9(9aH)-one derivatives.

Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2-Indolylmethanols as 3 C Building Blocks

The first catalytic asymmetric cycloaddition using 2-indolylmethanols as 3C building blocks has been established by a chiral phosphoric acid-catalyzed enantioselective and regioselective [3+3] cycloaddition of 2-indolylmethanols with azomethine ylides, which constructed biologically important tetrahydro-γ-carboline frameworks in high yields and excellent enantioselectivities (up to 83 % yield, 99:1 e.r.). This reaction not only represents the first application of 2-indolylmethanols as 3C building blocks in catalytic asymmetric cycloadditions, but also has established an abnormal regioselectivity in indolylmethanol-involved transformations.

Catalytic chemoselective [3+3] cycloadditions of azomethine ylides with quinone monoimides leading to the construction of a dihydrobenzoxazine scaffold

A chemoselective [3+3] cycloaddition of in situ generated azomethine ylides with quinone monoimides has been established, which efficiently led to the construction of dihydrobenzoxazine frameworks with biological relevance, with excellent chemoselectiviti

Br?nsted Acid-Catalyzed Three-Component 1,3-Dipolar Cycloadditions of 1,2-Disubstituted Alkynes with Aldehyde-Generated Azomethine Ylides

The first 1,3-dipolar cycloadditions (1,3-DCs) of 1,2-disubstituted alkynes with aldehyde-generated azomethine ylides have been established, leading to the efficient synthesis of poly-substituted 2,5-dihydropyrroles.The Br?nsted acid-catalyzed three-compo

Asymmetric organocatalytic formal double-arylation of azomethines for the synthesis of highly enantiomerically enriched isoindolines

Isoindoline derivatives with high enantiomeric purity (up to 98% ee) have been accessed by formal double arylation of azomethines.

One-pot, three-component, highly diastereoselective metal-free synthesis of 2,3,4,5-tetrasubstituted pyrrolidines

An extremely efficient, highly diastereoselective, metal-free synthesis of 2,3,4,5-tetrasubstituted pyrrolidines is described. The three-component reaction between aldehydes, aminomalonates, and nitroalkenes proceeds with high diastereoselectivities and h