7630-50-4Relevant academic research and scientific papers
Luxandrine, a quaternary benzylisoquinoline from Pseudoxandra sclerocarpa
Cortes, Diego,Wannigama, G.Percy,Saez, Jairo,Cave, Andre
, p. 2693 - 2695 (1986)
A new 6,7-dihydroxytetrahydrobenzylisoquinoline has been isolated and identified from the quaternary alkaloidal fraction of the bases of Pseudoxandra sclerocarpa.
Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro
Chia, Yi-Chen,Chang, Fang-Rong,Wu, Chin-Chung,Teng, Che-Ming,Chen, Keh-Shaw,Wu, Yang-Chang
, p. 1238 - 1241 (2007/10/03)
Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)-N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5′-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships. Georg Thieme Verlag KG Stuttgart.
