7630-74-2

Basic information

• Product Name: 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline
• Synonyms: 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline;Dehydronuciferine;dehydronuciferin
• CAS NO: 7630-74-2
• Molecular Formula: C19H19NO2
• Molecular Weight: 293.35966
• Mol File: 7630-74-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 493.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.193±0.06 g/cm3(Predicted)
• PKA: 4.04±0.20(Predicted)
• CAS DataBase Reference: 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline(7630-74-2)
• EPA Substance Registry System: 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline(7630-74-2)

Safety Data

• Hazardous Substances Data: 7630-74-2(Hazardous Substances Data)

Usage

General Description

The chemical 5,6-Dihydro-1,2-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline, also known as acronycine, is a natural alkaloid compound that has shown potential anti-cancer properties. It is isolated from the bark of the Australian shrub Acronychia baueri and has been studied for its ability to inhibit the growth of various cancer cells. Acronycine is believed to exert its anti-cancer effects through mechanisms such as DNA intercalation, topoisomerase inhibition, and disruption of microtubule function. Research on this compound is ongoing, and it holds promise as a potential anti-cancer agent.

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Relevant articles and documents

THREE BIS-DEHYDROAPORPHINES FROM OXANDRA CF. MAJOR

The structures of urabaine, N-methylurabaine and N,N'-dimethylurabaine, three new 7,7'-bis-dehydroaporphine alkaloids from Oxandra cf. major, have been elucidated by spectroscopic analysis and synthesis. - Key Word Index: Oxandra cf. major; Annonaceae; 7,7'-bisdehydroaporphine alkaloids; urabaine.

Total Syntheses of Aporphine Alkaloids via Benzyne Chemistry: An Approach to the Formation of Aporphine Cores

Total syntheses of lysicamine, (±)-nuciferine, (±)-nornuciferine, (±)-zanthoxyphylline iodide, (±)-O-methylisothebaine, and (±)-trimethoxynoraporphine were accomplished by an approach that involves the formation of aporphine cores through reactions betwee

The palladium(0) Suzuki cross-coupling reaction as the key step in the synthesis of aporphinoids

We report a flexible approach to the total synthesis of 4,5-dioxoaporphines based on the palladium(0) catalyzed Suzuki cross-coupling of phenylboronic acids with sterically hindered 2-bromo phenyl acetates or bromo phenyl acetamides, followed by sequential bicyclization of biarylacetamides promoted by oxalyl chloride/Lewis acid. The reduction of 4,5-dioxoaporphines provides a chemoselective entry to aporphines, dehydroaporphines and 4-hydroxy- dehydroaporphines. A three-steps total synthesis for (±)-O,O′- dimethylapomorphine from readily accessible precursors is also reported.