76306-60-0

Upstream product

• 155955-78-5 3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide 
• 29955-23-5 1-Phenyl-2-(3,4-dimethoxyphenyl)ethanone 
• 108-24-7 acetic anhydride 
• 76306-68-8 N-<2-(3,4-dimethoxyphenyl)-1-phenylethyl>formamide 
• 43071-00-7 (+/-)-α-phenyl-β-(3,4-dimethoxy)phenethylamine 

Downstream Products

• 76306-41-7 6,7-dimethoxy-1-methyl-3-phenyl-3,4-dihydroisoquinoline 
• 135365-14-9 8,9-Dimethoxy-10b-methyl-5-phenyl-6,10b-dihydro-5H-oxazolo[2,3-a]isoquinoline-2,3-dione 

Relevant academic research and scientific papers

(+/-)alpha-Phenyl-beta-(3,4-dimethoxy)- and (+/-)alpha-phenyl-beta -(3,4-dihydroxy)phenethylamines: potential probes for nicotinic acetylcholine receptor-ion channel molecule from torpedo electric organ.

The synthesis of some N-methyl, N-alkyl derivatives of (+/-)alpha-phenyl-beta-(3,4-dimethoxy)- and (+/-)alpha-phenyl-beta-(3,4-dihydroxy)-phenethylamines was achieved. These compounds were shown to bear certain structural features of acetylcholine (ACh),

A Modified Bischler-Napieralski Procedure for the Synthesis of 3-Aryl-3,4-dihydroisoquinolines

A modification of the Bischler-Napieralski reaction for the cyclization of (1,2-diphenylethyl)amides to the 3-aryl-3,4-dihydroisoquinolines is presented.Elimination of the amide group as the nitrile via the retro-Ritter reaction is avoided by its conversion to an N-acyliminium intermediate with oxalyl chloride-FeCl3.Removal of the oxalyl group in refluxing MeOH-sulfuric acid provides the 3,4-dihydroisoquinolines in moderate to high yields.The method is also highly effective with (2-phenylethyl)amides.