763103-10-2

Upstream product

• 763103-09-9 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-[6-(2-trimethylsilanyl-ethoxycarbonylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 
• 17318-24-0 3',5'-di-O-acetyl-2'-deoxyadenosine 
• 20160-60-5 2-(trimethylsilyl)-ethoxycarbonyl chloride 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 742104-25-2 N⁶-Teoc-dA 

Relevant academic research and scientific papers

Silyl protecting groups for oligonucleotide synthesis removed by a ZnBr2 treatment

An oligonucleotide protected with N-(trimethylsilyloxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups was synthesized and deprotected by a single ZnBr2 treatment. Finally it was released from the solid support by cleavage of a disul

Lewis acid deprotection of silyl-protected oligonucleotides and base-sensitive oligonucleotide analogues

a- a- a- Oligonucleotides protected with N-(trimethylsilylethoxycarbonyl) (Teoc) and P-(trimethylsilylethanol) (Tse) groups were synthesized and deprotected by a single ZnBr2 treatment. Teoc group stabilized dA against depurination. This strategy was applied to the synthesis of base-sensitive oligonucleotide prodrugs bearing S-acetyl-2-thioethyl (Sate) phosphotriesters.