76312-31-7

Upstream product

• 40535-14-6 3-methyl-1H-pyrazole-5-carbohydrazide 
• 4027-57-0 ethyl 5-methyl-2H-pyrazole-3-carboxylate 
• 108-94-1 cyclohexanone 
• 89270-69-9 5-Methyl-1H-pyrazole-3-carboxylic acid cyclohexylidene-hydrazide 

Downstream Products

• 76312-22-6 6-Cyclohexyl-2-methyl-6,7-dihydro-5H-pyrazolo[1,5-d][1,2,4]triazin-4-one 
• 115703-65-6 6-Cyclohexyl-2,7,7-trimethyl-6,7-dihydro-5H-pyrazolo[1,5-d][1,2,4]triazin-4-one 
• 76312-24-8 C₁₂H₁₆N₄O 

Relevant academic research and scientific papers

Pyrazolecarboxylic acid hydrazides as antiinflammatory agents. New selective lipoxygenase inhibitors

The synthesis and antiinflammatory activity of some new pyrazolecarboxylic acid hydrazides 3, 4 and 5 substituted with alkyl, alkylidene, aryl and acyl groups are described. 3 were prepared by reaction of pyrazolecarboxylic acids, esters, acid chlorides or diketopiperazines with hydrazines. Upon reaction with carbonyl compounds 3 gave hydrazones 4. Acylation of 3 yielded mono or bisacyl compounds 5. The most potent antiinflammatory compounds were among the N'-aryl hydrazides. These showed high lipoxygenase inhibitory activity but hardly inhibited cyclooxygenase enzyme.