763120-58-7Relevant articles and documents
Preparation method of nitrogen unsubstituted pyrazole and indazole boric acid
-
Paragraph 0029-0031; 0034-0036, (2020/01/12)
The invention discloses a method for preparing nitrogen unsubstituted pyrazole and indazole boric acid. Nitrogen unsubstituted halogenated pyrazole and a derivative thereof, or nitrogen unsubstitutedhalogenated indazole and a derivative of the nitrogen unsubstituted halogenated indazole react with triisopropylchlorosilane in an organic solvent to generate a triisopropylsilyl protected halogenatedpyrazole or halogenated indazole compound, then a lithium-bromine exchange reaction is carried out with n-butyl lithium, a borate is added to introduce boron atoms, and the nitrogen unsubstituted pyrazole or indazole boric acid is obtained in high yield after hydrolysis.