763122-73-2Relevant academic research and scientific papers
2,3,5-Trisubstituted pyridines as selective AKT inhibitors-Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity
Lin, Hong,Yamashita, Dennis S.,Zeng, Jin,Xie, Ren,Wang, Wenyong,Nidarmarthy, Sirishkumar,Luengo, Juan I.,Rhodes, Nelson,Knick, Victoria B.,Choudhry, Anthony E.,Lai, Zhihong,Minthorn, Elisabeth A.,Strum, Susan L.,Wood, Edgar R.,Elkins, Patricia A.,Concha, Nestor O.,Heerding, Dirk A.
scheme or table, p. 673 - 678 (2010/07/05)
2,3,5-Trisubstituted pyridines have been designed as potent AKT inhibitors that are selective against ROCK1 based on the comparison between AKT and ROCK1 structures. Substitution at the 2-position of the core pyridine is the key element to provide selectivity against ROCK1. An X-ray co-crystal structure of 9p in PKA supports the proposed rationale of ROCK1 selectivity.
INHIBITORS OF AKT ACTIVITY
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Page/Page column 54; 144, (2010/02/14)
Invented are novel pyridine compounds, the use of such compounds as inhibitors of PKB/AKT kinase activity and in the treatment of cancer and arthritis.
Assembling heterocycle-tethered C-glycosyl and α-amino acid residues via 1,3-dipolar cycloaddition reactions
Dondoni, Alessandro,Giovannini, Pier Paolo,Massi, Alessandro
, p. 2929 - 2932 (2007/10/03)
(Equation Presented) The 1,3-dipolar cycloadditions of C-glycosyl nitrile oxides and acetylenes to an alkyne and an azide, respectively, bearing a masked glycinyl moiety furnished disubstituted isoxazoles and triazoles. Unveiling the glycinyl group in the
