763123-60-0

Basic information

• Product Name: 4-(3-chloro-6-methoxypyridin-2-ylamino)-7-hydroxy-5-isopropoxyquinazoline
• Synonyms: 4-(3-chloro-6-methoxypyridin-2-ylamino)-7-hydroxy-5-isopropoxyquinazoline
• CAS NO: 763123-60-0
• Molecular Weight: 360.8
• Mol File: 763123-60-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 500.1±50.0 °C(Predicted)
• Density: 1.382±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 4-(3-chloro-6-methoxypyridin-2-ylamino)-7-hydroxy-5-isopropoxyquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-chloro-6-methoxypyridin-2-ylamino)-7-hydroxy-5-isopropoxyquinazoline(763123-60-0)
• EPA Substance Registry System: 4-(3-chloro-6-methoxypyridin-2-ylamino)-7-hydroxy-5-isopropoxyquinazoline(763123-60-0)

Safety Data

• Hazardous Substances Data: 763123-60-0(Hazardous Substances Data)

Upstream product

• 17920-35-3 2-amino-6-methoxypyridine 

Relevant articles and documents

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors. Highly potent inhibition, high selectivity and physical properties suitable for oral dosing were achieved within this series: 23d and 42 were identified as sub-0.1 μM inhibitors in a c-Src-driven cell proliferation assay and displayed adequate rat pharmacokinetics after oral administration.