763132-62-3Relevant articles and documents
Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
Li, Zi-Lin,Li, Qing-Shan,Zhang, Hong-Jia,Hu, Yang,Zhu, Di-Di,Zhu, Hai-Liang
experimental part, p. 4413 - 4420 (2011/09/19)
FabH, β-ketoacyl-acyl carrier protein (ACP) synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and Gram-negative bacteria. A series of o-hydroxybe
Synthesis of substituted salicylamines and dihydro-2H-1,3-benzoxazines
Anwar, Hany F.,Skatteb?l, Lars,Hansen, Trond Vidar
, p. 9997 - 10002 (2008/02/13)
Phenols were converted to their magnesium salts with the MgCl2-Et3N base system and subsequently reacted with Eschenmoser's salt, affording N,N-dimethyl substituted benzylamines in high to excellent yields. A series of mono N-substituted benzylamines were prepared in one-pot syntheses by ortho-formylation of phenols to corresponding salicylaldehydes, which in turn reacted with amines to imines. The imines were subsequently reduced to mono N-substituted benzylamines. Some of these benzylamines were further converted, without work-up, to mono N-substituted dihydro-2H-1,3-benzoxazines.
