76315-55-4

Basic information

• Product Name: 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE
• Synonyms: 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE;1H-Indole, 6-fluoro-3-(4-piperidinyl)-
• CAS NO: 76315-55-4
• Molecular Formula: C₁₃H₁₅FN₂
• Molecular Weight: 218.27
• Mol File: 76315-55-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 391.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.190±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 16.46±0.30(Predicted)
• CAS DataBase Reference: 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE(76315-55-4)
• EPA Substance Registry System: 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE(76315-55-4)

Safety Data

• Hazardous Substances Data: 76315-55-4(Hazardous Substances Data)

Usage

General Description

6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE is a chemical compound with the molecular formula C14H16FN2. It is an indole derivative with a piperidine ring and a fluorine atom attached to the 6th carbon. 6-FLUORO-3-PIPERIDIN-4-YL-1H-INDOLE has potential pharmacological and medicinal applications due to its structural features and properties. It is commonly used in the synthesis of various pharmaceutical drugs and research compounds. Furthermore, its unique structure and functional groups make it a valuable tool in the development of new therapeutic agents and drug candidates. Additionally, it is important to handle this compound with caution and adhere to proper safety protocols and guidelines when working with it in a laboratory setting.

Upstream product

• 180161-14-2 6-fluoro-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole 
• 314083-18-6 6-fluoro-3-(1-benzyl-2H,3H,6H-4-azinyl)indole 
• 107-21-1 ethylene glycol 
• 399-51-9 6-fluoro-1H-indole 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 41661-47-6 piperidin-4-one 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 423174-02-1 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic Acid Ethyl Ester 
• 423173-96-0 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic Acid Ethyl Ester 

Relevant articles and documents

NEW HETEROCYCLIC COMPOUNDS

The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Substituted heterocyclic compounds and its application on the medicament (by machine translation)

The invention relates to substituted heterocyclic compounds and its application on the medicament, in particular to a novel class of substituted heterocyclic compounds or its isomer, tautomer, nitrogen oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug, and their method of preparation. The invention also relates to the compounds of the invention pharmaceutical composition, and said compound or pharmaceutical compositions for the treatment5-HT6receptor-related diseases, in particular Alzheimer's disease in the use thereof. (by machine translation)

Synthesis and structure-activity relationships of novel histamine H 1 antagonists: Indolylpiperidinyl benzoic acid derivatives

A series of indolylpiperidinyl derivatives were prepared and evaluated for their activity as histamine H1 antagonists. Structure-activity relationship studies were directed toward improving in vivo activity and pharmacokinetic profile of our first lead (1). Substitution of fluorine in position 6 on the indolyl ring led to higher in vivo activity in the inhibition of histamine-induced cutaneous vascular permeability assay but lower selectivity toward 5HT2 receptor. Extensive optimization was carried out within this series and a number of histamine H1 antagonists showing potency and long duration of action in vivo and low brain penetration or cardiotoxic potential were identified. Within this novel series, indolylpiperidines 15, 20, 48, 51 and 52 exhibited a long half-life in rat and have been selected for further preclinical evaluation.