76322-78-6

Usage

Chemical structure

A pyrrole derivative with a methoxymethyl group attached to the nitrogen atom

Applications

a. Building block in organic synthesis
b. Preparation of pharmaceuticals and agrochemicals
c. Production of dyes, pigments, and specialty chemicals

Biological activities

a. Antimicrobial properties
b. Antifungal properties

Fields of use

a. Medicine
b. Agriculture

Upstream product

• 109-97-7 pyrrole 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 107902-40-9 1-Methoxymethyl-2-((E)-styryl)-1H-pyrrole 
• 164262-48-0 1-(methoxymethyl)-4-nitropyrrole-2-carboxylic acid 
• 164262-52-6 ethyl 1-methoxymethyl-4-aminopyrrole-2-carboxylate 

Relevant academic research and scientific papers

Cyclopropylpyrroloindole-oligopeptide anticancer agents

The invention is directed to novel cyclopropylpyrroloindole-oligopeptide compounds which are useful as anticancer agents. The novel cyclopropylpyrroloindole-oligopeptide compounds have the following general structure: STR1 wherein, Het1 and Het2 are individually selected from the group consisting of pyrrole, imidazole, triazole, thiophene, furan, thiazole, oxazole and pyrazole, R is selected from the group consisting of a valence bond; a C1 -C6 alkyl; a C2 -C6 alkenyl; a C2 -C6 alkynyl; and an ortho, meta or para linked aromatic group, A is selected from the group consisting of a C1 -C6 alkyl group; an amidine or derivative thereof; a guanidine; a secondary, tertiary or quaternary ammonium salt; and a sulfonium salt, n is 0 to 3, and m is 0 to 3.

SYNTHESIS OF A NOVEL N-METHOXYMETHYLPYRROLE-CONTAINING DNA MINOR GROOVE BINDING OLIGOPEPTIDE RELATED TO DISTAMYCIN

A novel N-methoxymethylpyrrole-containing DNA minor groove binding oligo-peptide designed for increased solubility and enhanced cellular uptake and related to distamycin has been synthesized.

Pyrrole Studies; 34. Synthesis of 1,2-Di(2-pyrrolyl)ethenes and Related Compounds

Novel 1,2-di(2-pyrrolyl)ethenes 5 and related compounds 8 have been prepared in good yield using the Wittig reaction.Although the Horner reaction can be used for the synthesis of 1,2-di(2-thienyl)- and 1,2-di(2-furyl)-ethenes, the procedure is not suitabl

On the Use of N,N'-Dipyrrolylmethane in Heterocyclic Synthesis. Dipyrrol-2H-imidazole and its Aromatic Anion

The pyrrolate ion (5) is shown to produce N, N'-dipyrrolyl methane (4) when reacted with dichloromethane under conditions of weak counter-ion association. 1-Azoniafulvene ion (13) is sggested to be the key intermediate in this reaction.N,N'-dipyrrolyl methane (4) undergoes intramolecular oxidative coupling when treated with butyllithium and Cu(II)chloride, yielding the novel ring system of dipyrrolo-2H-imidazole (3).The latter upon reaction with methyl lithium forms the Hueckel-aromatic anion 2.Solutions of the lithium salt are stable for several days.Reaction of the dianion of 2,2'-bipyrrole (11) with dichloromethane doesi40 not produce 3, but a pyrrolophane-type dimer (12) having its two anticoplanar N,N'-bipyrrolediyl subunits arranged in a double layer and joined by a methylene group on each side.