76327-75-8Relevant academic research and scientific papers
1,3-Cyclohexanedione derivatives
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, (2008/06/13)
Novel cyclohexanone derivatives of general formula: STR1 (wherein R1 is a hydrocarbon group of 1 to 15 carbon atoms) and new cyclohexanone derivatives of general formula: STR2 (wherein R1 and R2 each is a hydrocarbon group of 1 to 15 carbon atoms) are produced by an electrooxidative coupling of 1,3-cyclohexanedione with a vinyl ether of general formula: (wherein R1 is as defined above) in the presence or absence of an alcohol of general formula: (wherein R2 is as defined above). These new cyclohexanone derivatives can be easily converted to N-substituted or unsubstituted-4-oxo-4,5,6,7-tetrahydroindoles, which are of value as intermediates for the production of N-substituted or unsubstituted-4-hydroxyindoles and, thence, to pindolol and its analogs.
A FACILE SYNTHESIS OF 4-HYDROXYINDOLE VIA ELECTROCHEMICAL OXIDATIVE C-C COUPLING
Torii, Sigeru,Uneyama, Kenji,Onishi, Takashi,Fujita, Yoshiji,Ishiguro, Michihiro,Nishida, Takashi
, p. 1603 - 1604 (2007/10/02)
4-hydroxyindole (1a), a useful intermediate for Pindolol (1b), has been prepared via electrooxidative coupling of 1,3-cyclohexadione with ethyl vinyl ether followed by ammonolysis and dehydrogenation.
