76330-71-7

Basic information

• Product Name: Altanserin
• Synonyms: 4(1H)-QUINAZOLINONE, 3-(2-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)ETHYL)-2,3-DIHYDRO-2-THIOXO-;ALTANSERIN;ALTANSERIN HYDROCHLORIDE;3-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,3-DIHYDRO-2-THIOXO-4(1H)-QUINAZOLINONE HYDROCHLORIDE;3-(2-(4-(4-Fluorobenzoyl)-1-piperidinyl)ethyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinonehydrochloride;AltanserineHCl;3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrate hydrochloride;Altanserin hydrate hydrochloride
• CAS NO: 76330-71-7
• Molecular Formula: C₂₂H₂₂FN₃O₂S
• Molecular Weight: 411.49
• EINECS: 278-422-1
• Product Categories: Serotonin receptor
• Mol File: 76330-71-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 580.2 ºC at 760 mmHg
• Flash Point: 304.7 ºC
• Appearance: Yellowish solid
• Density: 1.37 g/cm³
• Vapor Pressure: 1.86E-13mmHg at 25°C
• Refractive Index: 1.674
• Storage Temp.: 2-8°C
• Solubility: DMSO: >5mg/mL
• CAS DataBase Reference: Altanserin(CAS DataBase Reference)
• NIST Chemistry Reference: Altanserin(76330-71-7)
• EPA Substance Registry System: Altanserin(76330-71-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 76330-71-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish solid

Uses

Altanserin Hydrochloride is a useful intermediate for organic synthesis.

Biological Activity

Potent and selective 5-HT 2A receptor antagonist (K i values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT 2A , α 1 , 5-HT 2C , D 2 and 5-HT 1A respectively). Centrally active following systemic administration in vivo .

InChI:InChI=1/C22H22FN3O2S/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)

Downstream Products

• 139418-52-3 [¹⁸F]altanaserine 

Relevant articles and documents

Piperidinylalkyl quinazoline compounds, composition and method of use

Novel quinazoline derivatives, comprising in the heterocyclic part of their quinazoline nucleus at least one carbonyl or thiocarbonyl group and a particularly substituted piperidinyl-alkyl side chain, said compounds being potent serotonin-antagonists.