76334-30-0Relevant academic research and scientific papers
Processes and intermediates for preparing fulvestrant
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Paragraph 0040-0043; 0048-0051, (2020/05/30)
The present invention provides a method and an intermediate for preparing fulvestrant, and relates to a method for preparing fulvestrant, and an intermediate (5) of fulvestrant, and a synthetic methodthereof. The method provided by the invention can be used for obtaining high-purity fulvestrant, and is suitable for industrial mass production.
Application of "click" chemistry in solid phase synthesis of alkyl halides
Das, Diparjun,Chanda, Tridib,Rokhum, Lalthazuala
, p. 775 - 783 (2016/01/20)
A convenient and highly selective microwave assisted procedure for the conversion of allylic, benzylic and aliphatic alcohols to their corresponding halides using polymer-bound triphenylphosphine and iodine is presented. In case of symmetrical diols, mono-iodination product is obtained in very high yield. Additionally, highly regioselective behavior is observed in our procedure. Simplicity in operation, no column chromatography required for the purification of the products, recyclability of the reagents used, short reaction times and good to excellent yields are the advantages of our protocol. Most functional groups remain unaffected under our reaction condition.
Synthesis and physical properties of ferrocene derivatives (XXV) liquid crystallinity of 1,3-disubstituted ferrocene derivatives
Nakamura, Naotake,Kagawa, Shinya
experimental part, p. 150 - 159 (2012/01/03)
Liquid crystallinity of 1,3-disubstituted ferrocene derivatives was studied by DSC and polarizing microscope. The name of the derivatives is 1,3-bis[-[4-(4-methoxyphenoxycarbonyl)phenoxy]alkyloxycarbonyl]ferrocene. Nine members from n = 2 to 10 were synthesized (n is carbon number of alkyl chain in the sample). All samples except n = 2 and 4 exhibited monotropic nematic liquid crystalline phase. In addition, smectic X (not yet completely identified) was also observed in n = 8 and 10. Liquid crystalline phase transition phenomena were discussed from a viewpoint of molecular shape. Copyright Taylor & Francis Group, LLC.
Synthesis and physical properties of ferrocene derivatives (XXIII): Phase transition and unique molecular structure of monosubstituted ferrocene derivatives
Nakamura, Naotake,Hiro, Kazuya,Nishikawa, Masako,Okabe, Takashi,Uno, Kenjiro
scheme or table, p. 122 - 131 (2010/08/05)
The monosubstituted ferrocene derivatives, -[4-(4-methoxyphenoxycarbonyl) phenoxy]alkoxycarbonyl ferrocene, were synthesized in order to compare the liquid crystallinity to that of disubstituted ferrocene derivatives, 1,1'-bis[-[4-(4-methoxy-phenoxycarbonyl)phenoxy]alkoxycarbonyl]ferrocene. Some of the monosubstituted ferrocene derivatives containing relatively longer flexible spacer showed the liquid crystalline phase, nematic and/or smectic phases. The crystal structure of 2-[4-(4-methoxyphenoxycarbonyl)phenoxy] ethoxycarbonyl ferrocene was determined by X-ray diffraction method using a single crystal. The molecular structure revealed a bent structure that is almost a half of "Z" shaped molecular structure of 1,1'-bis[2-[4-(4- methoxyphenoxycarbonyl)phenoxy]ethoxycarbonyl]ferrocene.
A New Synthetic Method of Macrocyclic Lactones from ω-Iodoalkylacrylates
Abe, Motoji,Hayashikoshi, Takaoki,Kurata, Takeo
, p. 1789 - 1792 (2007/10/02)
When the photostimulated cyclization reaction of ω-iodoalkylacrylates was performed in the presence of metal hydride complexes such as sodium cyanoborohydride (NaBH3CN), sodium borohydride (NaBH4) and potassium borohydride (KBH4), the corresponding macrocyclic lactones were produced.The use of NaBH3CN led to the highest yield of lactones.
