76335-80-3

Upstream product

• 76335-79-0 4-benzyloxy-1,3-dimethoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 40232-88-0 4-benzyloxy-3-methoxyphenol 

Downstream Products

• 1443655-54-6 1-(5-hydroxy-2,4-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)propane 
• 88775-56-8 2-(5-benzyloxy-2,4-dimethoxyphenyl)-4-(3,4-dimethoxyphenyl)-4-oxobutyramide 
• 88775-55-7 2-(5-benzyloxy-2,4-dimethoxyphenyl)-4-(3,4,-dimethoxyphenyl)-4-oxobutyronitrile 
• 107644-07-5 4',7-dibenzyloxy-2',3,4',5,6,8-hexamethoxyflavone 
• 107644-10-0 3,5',7-trihydroxy-2',4',5,6,8-pentamethoxyflavone 
• 100363-95-9 5,7,5'-trihydroxy-3,6,8,2',4'-pentamethoxyflavone 
• 100363-91-5 5',7-dibenzyloxy-3-hydroxy-2',4',5,6,8-pentamethoxyflavone 
• 88775-53-5 5-benzyloxy-2,4,3',4'-tetramethoxychalcone 
• 107644-04-2 4',5-dibenzyloxy-2'-hydroxy-2,3',4,5',6'-pentamethoxychalcone 

Relevant academic research and scientific papers

Studies on the chemical constituents of rutaceous plants. XLIX. Development of a versatile method for the synthesis of antitumor-active benzo[c]phenanthridine alkaloids. (1). Preparation of various 2,4-bisaryl-4-oxobutyronitriles and 2,4-bisaryl-4-oxobutyramides

For the sake of establishment of a versatile synthetic method for benzo[c]phenanthridine alkaloids, improvement of the Robinson synthetic method was examined. Thirteen chalcones (7a-m) were prepared by condensation of two acetophenone derivatives (15 and 16) with eleven benzaldehyde derivatives (19a-k) as fundamental starting materials. Hydrocyanation of these chalcones (7a-1) except one (7m) gave the corresponding 2,4-bisaryl-4-oxobutyronitriles (8a-1). Eleven 2,4-bisaryl-4-oxobutyramides (9a-k) were also prepared.