76336-69-1Relevant academic research and scientific papers
SYNTHESIS OF (+/-)-JATROPHAM, AN ANTITUMOR ALKALOID FROM JATROPHA MACRORHIZA
Yakushijin, Kenichi,Suzuki, Rika,Hattori, Ren,Furukawa, Hiroshi
, p. 1157 - 1160 (2007/10/02)
The synthesis of jatropham, assigned as 5-hydroxy-3-methyl-3-pyrrolin-2-one 4, and of its 4-methyl isomer 14 is achieved utilizing an autoxidation of 2-furylcarbamates 2 and 11 as the key step.
RING TRANSFORMATION OF 2-FURYLCARBAMATES TO 5-HYDROXY-3-PYRROLIN-2-ONES. REVISED STRUCTURE OF JATROPHAM
Yakushijin, Kenichi,Kozuka, Masamichi,Ito, Yoko,Suzuki, Rika,Furukawa, Hiroshi
, p. 1073 - 1076 (2007/10/02)
2-Furylcarbamates 1-7 react with oxygen under stirring or irradiation in benzene at room temperature to give the corresponding N-substituted 5-hydroxy-3-pyrrolin-2-ones 8-14.In the syntheses and NMR experiments of these pyrrolinone derivatives, the structure of jatropham 27, one of pyrrolinone derivatives proposed by Cole et al., is revised to the formula 11 (R1=H).
