76337-97-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(cyclopent-2-en-1-yl)propanoic acid is used as a precursor for the synthesis of various drugs and bioactive molecules, contributing to the development of new therapeutic agents.
Used in Organic Synthesis:
2-(cyclopent-2-en-1-yl)propanoic acid is used as a versatile building block for the preparation of various functionalized derivatives, enabling the creation of a wide range of chemical compounds in the field of organic chemistry.

Upstream product

• 83974-29-2 cyclopent-2-enyl-methyl-malonic acid diethyl ester 
• 53608-93-8 diethyl 2-(cyclopenten-1-yl)propane-1,3-dioate 
• 134132-75-5 tert-Butyl-[(E)-1-(cyclopent-2-enyloxy)-propenyloxy]-dimethyl-silane 
• 3212-60-0 cyclopent-2-enol 
• 35116-18-8 2-cyclopentenyl propanoate 
• 930-30-3 cyclopent-2-enone 

Downstream Products

• 76338-03-9 C₁₇H₂₄N₂O₃S 

Relevant academic research and scientific papers

Stereochemical Control in the Ester Enolate Claisen Rearrangement. 2. Chairlike vs Boatlike Transition-State Selection

The preference for chair-and boatlike transition-state geometries in the ester enolate Claisen rearrangement of straight chain, carbocyclic, and heterocyclic propanoates was investigated.A novel stereoelectronic effect in pyranoid and furanoid glycal systems leads to a significant relative stabilisation of the boatlike vs the chairlike TS(excit.).The preferred transition state in six- and five-membered carbocyclic systems is highly dependent on steric factors, as the energy difference between chair-and boatlike TS(excit.) tends to be small.With straight-chain substrates, a significant contribution of the boatlike TS(excit.) to the rearrangement product mixture is only expected in bis-donor substituted allylic esters.

Azaprostacyclins, their preparation and pharmaceutical use

Azaprostacyclins of Formula I STR1 wherein R1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy, W is a free or functionally modified carbonyl group or a STR2 wherein R8 is hydrogen or alkyl of 1-5 carbon atoms and R9 is hydrogen or a readily cleavable ether or acyl residue and wherein the OR9 -group can be in the α- or β-position, R2 is a free or functionally modified hydroxy group.

TRICYCLO2,8>OCTANONES AS BUILDING BLOCKS IN NATURAL PRODUCTS SYNTHESIS (I). --THE SYNTHESIS OF CHRYSOMELIDIAL--

The stereocontrolled synthesis of chrysomelidial from 4-methyl-tricyclo2,8>octan-3-one is described.